PATENTS RELATED TO ENDOTOXIN

Although Dr. Demchick also represents patent seekers with non-microbiological inventions, his doctorate is in microbiology. Microbiology has been the primary focus of his research and teaching. He especially loves dealing with patent searches and applications for involving microbiology.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.

If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.

The following sampling is to give you some sense of the types of endotoxin related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.

It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Water-soluble chitosan having low endotoxin concentration and methods for making and using the same (United States Patent 7,125,967)

Process for the depletion or removal of endotoxins (United States Patent 7,109,322)

Lepidopteran-active Bacillus thuringiensis delta-endotoxin polynucleotides, compositions, and methods of use (United States Patent 7,078,509)

Polynucleotide compositions encoding broad spectrum delta-endotoxins (United States Patent 7,070,982)

Plants transformed to express Cry2A .delta.-endotoxins (United States Patent 7,064,249)

Polynucleotides encoding .DELTA.-endotoxins toxic to lepidoptera and coleoptera, and method of use (United States Patent 7,022,897)

Hybrid Bacillus thuringiensis .delta.-endotoxins with novel broad-spectrum insecticidal activity (United States Patent 6,962,705)

Antibodies immunologically reactive with broad-spectrum delta endotoxins (United States Patent 6,951,922)

Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases (United States Patent 6,951,652)

Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography (United States Patent 6,942,802)

Methods and kits for the detection of endotoxin (United States Patent 6,908,742)

Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin (United States Patent 6,894,150)

Method for producing endotoxin-free nucleic acids and the use thereof (United States Patent 6,855,816)

Methods and reagents for detecting endotoxin (United States Patent 6,849,426)

Extracorporeal endotoxin removal method (United States Patent 6,774,102)

Adsorption and removal of endotoxin from physiological fluids using cationic helix peptides (United States Patent 6,756,206)

Antibodies immunologically reactive with broad-spectrum .delta. endotoxins (United States Patent 6,746,871)

Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics (United States Patent 6,719,973)

Method for removing endotoxin from the samples containing basic protein (United States Patent 6,713,611)

Broad-spectrum .delta.-endotoxins (United States Patent 6,713,063)

Endotoxin adsorbent, and a method of removing endotoxin by using the same (United States Patent 6,699,386)

Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs (United States Patent 6,683,063)

Assays for endotoxin (United States Patent 6,645,724)

Polynucleotide compositions encoding broad-spectrum .delta. endotoxins (United States Patent 6,645,497)

Synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome (United States Patent 6,624,140)

Medical device containing polyhydroxyalkanoate treated with oxidizing agent to remove endotoxin (United States Patent 6,623,749)

Method for removing endotoxins (United States Patent 6,617,443)

Lepidopteran-active Bacillus thuringiensis .delta.-endotoxin compositions and methods of use (United States Patent 6,593,293)

Polynucleotide compositions encoding broad spectrum delta-endotoxins (United States Patent 6,538,109)

Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis (United States Patent 6,534,648)

Polynucleotide compositions encoding broad spectrum .delta.-endotoxins (United States Patent 6,521,442)

Biocontrol agent containing an endotoxin gene (United States Patent 6,503,500)

Methods for transforming plants to express Cry2Ab .delta.-endotoxins targeted to the plastids (United States Patent 6,489,542)

Process of its application against lepidopteran insects using Albizzia lebbeck plant extract and Bacilus thuriengiensis delta-endotoxin (United States Patent 6,455,079)

Biopolymer salts with low endotoxin levels, biopolymer compositions thereof and methods of making the same (United States Patent 6,451,772)

Method for reducing adverse effects of a human 70kDa mediator which results from endotoxin stimulation of macrophages (United States Patent 6,419,927)

Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs (United States Patent 6,417,172)

Therapeutic drug for endotoxin blood symptom and multi-organ failure induced thereby (United States Patent 6,395,717)

Methods and compositions for the detection of bacterial endotoxins (United States Patent 6,391,570)

Endotoxin binding and neutralizing protein and uses thereof (United States Patent 6,384,200)

Methods for removing endotoxins from biological solutions using immobilized metal affinity chromatography (United States Patent 6,365,147)

Deposit assessment of Bacillus thuringiensis delta-endotoxin (United States Patent 6,344,338)

Polynucleotide compositions encoding Cry1Ac/Cry1F chimeric O-endotoxins (United States Patent 6,326,169)

Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) (United States Patent 6,309,640)

Ice granules containing endotoxins of Bacillus thuringiensis israelensis (BTI) or Bacillus sphaericus (BS) (United States Patent 6,303,117)

Process for the preparation of endotoxin-free or endotoxin-depleted nucleic acids and/or oligonucleotides for gene therapy (United States Patent 6,297,371)

Method of dephosphorylating an endotoxin in vivo with alkaline phosphatase (United States Patent 6,290,952)

Methods and compositions for the detection of bacterial endotoxins (United States Patent 6,270,982)

Recombinant endotoxin-neutralizing proteins (United States Patent 6,265,187)

Removing endotoxin with an oxdizing agent from polyhydroxyalkanoates produced by fermentation (United States Patent 6,245,537)

Polynucleotide compositions encoding broad-spectrum .delta.-endotoxins (United States Patent 6,242,241)

Fragments of endotoxin binding protein and uses thereof (United States Patent 6,222,021)

Chimeric bacillus thuringiensis-endotoxins and host cells expressing same (United States Patent 6,221,649)

Bacillus thuringiensis mutants which produce higher yields of crystal delta-endotoxin than their corresponding parental strains (United States Patent 6,210,952)

Endotoxin reduction in nucleic acid purification (United States Patent 6,194,562)

Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis (United States Patent 6,172,220)

Detection and quantitation of endotoxin by fluorescence polarization (United States Patent 6,171,807)

Hybrid Bacillus thuringiensis .delta.-endotoxins with novel broad-spectrum insecticidal activity (United States Patent 6,156,573)

Endotoxin adsorption system (United States Patent 6,132,610)

Broad-spectrum .delta.-endotoxins (United States Patent 6,110,464)

Transformation vectors allowing expression of truncated BT2 endotoxins in plants (United States Patent 6,107,546)

Methods for improving the activity of .delta.-endotoxins against insect pests (United States Patent 6,077,824)

Bacillus thuringiensis endotoxin genes and methods of use (United States Patent 6,063,605)

Myeloperoxidase assay of endotoxin-induced inflammation (United States Patent 6,022,699)

Hybrid Bacillus thuringiensis .delta.-endotoxins with novel broad-spectrum insecticidal activity (United States Patent 6,017,534)

Detection of endotoxin levels in liposomes, lipid bilayers and lipid complexes (United States Patent 6,015,716)

Compositions and methods for use in ischemia-reperfusion and endotoxin-related tissue injury (United States Patent 6,001,842)

Endotoxin-specific assay (United States Patent 5,998,389)

Process for remediating endotoxin-contaminated bulk non-ionic contrast media (United States Patent 5,972,225)

Vaccine and serum for endotoxin associated disease immunization and treatment, detoxified endotoxin, and bacterial mutant (United States Patent 5,961,985)

Bacillus thuringiensis .delta.-endotoxin (United States Patent 5,932,209)

Process for removing endotoxins (United States Patent 5,917,022)

Transgenic plants expressing lepidopteran-active .delta.-endotoxins (United States Patent 5,914,318)

Endotoxin stabilizing agent, endotoxin composition and method for assaying endotoxin (United States Patent 5,876,955)

Bacillus thuringiensis mutants which produce high yields of crystal delta-endotoxin (United States Patent 5,874,289)

Anti-endotoxin compounds (United States Patent 5,843,918)

Transformation vectors allowing expression of foreign polypeptide endotoxins in plants (United States Patent 5,843,898)

.beta.-Endotoxin expression in pseudomonas fluorescens (United States Patent 5,840,554)

Reagent for endotoxin assay and method for endotoxin assay using the same (United States Patent 5,840,510)

Use of interleukin-10 analogs for antagonists to treat endotoxin- or superantigen-induced toxicity (United States Patent 5,837,293)

Use of interleukin-10 (IL-10) to treat endotoxin- or superantigen-induced toxicity (United States Patent 5,833,976)

Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use (United States Patent 5,830,860)

Treatment of endotoxin-associated disorders with cationic peptides (United States Patent 5,789,377)

Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use (United States Patent 5,786,324)

Methods and kits for the detection of endotoxin (United States Patent 5,773,306)

Transformation vectors allowing expression of foreign polypeptide endotoxins from Bacillus thuringiensis in plants (United States Patent 5,767,372)

Endotoxins (United States Patent 5,760,181)

Anti-endotoxin compounds (United States Patent 5,756,718)

Process for inhibiting activity of endotoxin (United States Patent 5,750,500)

Process for the depletion or removal of endotoxins (United States Patent 5,747,663)

Endotoxin binding and neutralizing protein and uses thereof (United States Patent 5,747,455)

Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists (United States Patent 5,733,916)

Bacillus thuringiensis .alpha.-endotoxin fragments (United States Patent 5,710,020)

Reagent for endotoxin-specific assay (United States Patent 5,702,882)

Bacillus thuringiensis mutants which produce high yelds of crystal delta-endotoxin (United States Patent 5,698,440)

Reagent for endotoxin assay and method for endotoxin assay using the same (United States Patent 5,695,948)

Treatment of endotoxin-associated disorders with cationic peptides (United States Patent 5,688,767)

Method for protecting against endotoxin-induced shock using ornithine (United States Patent 5,686,493)

Methods and compositions useful in prophylaxis and therapy of endotoxin related conditions (United States Patent 5,674,855)

Water-soluble chitosan having low endotoxin concentration and methods for making and using the same (United States Patent 7,125,967)

Process for the depletion or removal of endotoxins (United States Patent 7,109,322)

Lepidopteran-active Bacillus thuringiensis delta-endotoxin polynucleotides, compositions, and methods of use (United States Patent 7,078,509)

Polynucleotide compositions encoding broad spectrum delta-endotoxins (United States Patent 7,070,982)

Plants transformed to express Cry2A .delta.-endotoxins (United States Patent 7,064,249)

Polynucleotides encoding .DELTA.-endotoxins toxic to lepidoptera and coleoptera, and method of use (United States Patent 7,022,897)

Hybrid Bacillus thuringiensis .delta.-endotoxins with novel broad-spectrum insecticidal activity (United States Patent 6,962,705)

Antibodies immunologically reactive with broad-spectrum delta endotoxins (United States Patent 6,951,922)

Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases (United States Patent 6,951,652)

Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography (United States Patent 6,942,802)

Methods and kits for the detection of endotoxin (United States Patent 6,908,742)

Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin (United States Patent 6,894,150)

Method for producing endotoxin-free nucleic acids and the use thereof (United States Patent 6,855,816)

Methods and reagents for detecting endotoxin (United States Patent 6,849,426)

Extracorporeal endotoxin removal method (United States Patent 6,774,102)

Adsorption and removal of endotoxin from physiological fluids using cationic helix peptides (United States Patent 6,756,206)

Antibodies immunologically reactive with broad-spectrum .delta. endotoxins (United States Patent 6,746,871)

Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics (United States Patent 6,719,973)

Method for removing endotoxin from the samples containing basic protein (United States Patent 6,713,611)

Broad-spectrum .delta.-endotoxins (United States Patent 6,713,063)

Endotoxin adsorbent, and a method of removing endotoxin by using the same (United States Patent 6,699,386)

Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs (United States Patent 6,683,063)

Assays for endotoxin (United States Patent 6,645,724)

Polynucleotide compositions encoding broad-spectrum .delta. endotoxins (United States Patent 6,645,497)

Synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome (United States Patent 6,624,140)

Medical device containing polyhydroxyalkanoate treated with oxidizing agent to remove endotoxin (United States Patent 6,623,749)

Method for removing endotoxins (United States Patent 6,617,443)

Lepidopteran-active Bacillus thuringiensis .delta.-endotoxin compositions and methods of use (United States Patent 6,593,293)

Polynucleotide compositions encoding broad spectrum delta-endotoxins (United States Patent 6,538,109)

Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis (United States Patent 6,534,648)

Polynucleotide compositions encoding broad spectrum .delta.-endotoxins (United States Patent 6,521,442)

Biocontrol agent containing an endotoxin gene (United States Patent 6,503,500)

Methods for transforming plants to express Cry2Ab .delta.-endotoxins targeted to the plastids (United States Patent 6,489,542)

Process of its application against lepidopteran insects using Albizzia lebbeck plant extract and Bacilus thuriengiensis delta-endotoxin (United States Patent 6,455,079)

Biopolymer salts with low endotoxin levels, biopolymer compositions thereof and methods of making the same (United States Patent 6,451,772)

Method for reducing adverse effects of a human 70kDa mediator which results from endotoxin stimulation of macrophages (United States Patent 6,419,927)

Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs (United States Patent 6,417,172)

Therapeutic drug for endotoxin blood symptom and multi-organ failure induced thereby (United States Patent 6,395,717)

Methods and compositions for the detection of bacterial endotoxins (United States Patent 6,391,570)

Endotoxin binding and neutralizing protein and uses thereof (United States Patent 6,384,200)

Methods for removing endotoxins from biological solutions using immobilized metal affinity chromatography (United States Patent 6,365,147)

Deposit assessment of Bacillus thuringiensis delta-endotoxin (United States Patent 6,344,338)

Polynucleotide compositions encoding Cry1Ac/Cry1F chimeric O-endotoxins (United States Patent 6,326,169)

Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) (United States Patent 6,309,640)

Ice granules containing endotoxins of Bacillus thuringiensis israelensis (BTI) or Bacillus sphaericus (BS) (United States Patent 6,303,117)

Process for the preparation of endotoxin-free or endotoxin-depleted nucleic acids and/or oligonucleotides for gene therapy (United States Patent 6,297,371)

Method of dephosphorylating an endotoxin in vivo with alkaline phosphatase (United States Patent 6,290,952)

Methods and compositions for the detection of bacterial endotoxins (United States Patent 6,270,982)

Recombinant endotoxin-neutralizing proteins (United States Patent 6,265,187)

Removing endotoxin with an oxdizing agent from polyhydroxyalkanoates produced by fermentation (United States Patent 6,245,537)

Polynucleotide compositions encoding broad-spectrum .delta.-endotoxins (United States Patent 6,242,241)

Fragments of endotoxin binding protein and uses thereof (United States Patent 6,222,021)

Chimeric bacillus thuringiensis-endotoxins and host cells expressing same (United States Patent 6,221,649)

Bacillus thuringiensis mutants which produce higher yields of crystal delta-endotoxin than their corresponding parental strains (United States Patent 6,210,952)

Endotoxin reduction in nucleic acid purification (United States Patent 6,194,562)

Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis (United States Patent 6,172,220)

Detection and quantitation of endotoxin by fluorescence polarization (United States Patent 6,171,807)

Hybrid Bacillus thuringiensis .delta.-endotoxins with novel broad-spectrum insecticidal activity (United States Patent 6,156,573)

Endotoxin adsorption system (United States Patent 6,132,610)

Broad-spectrum .delta.-endotoxins (United States Patent 6,110,464)

Transformation vectors allowing expression of truncated BT2 endotoxins in plants (United States Patent 6,107,546)

Methods for improving the activity of .delta.-endotoxins against insect pests (United States Patent 6,077,824)

Bacillus thuringiensis endotoxin genes and methods of use (United States Patent 6,063,605)

Myeloperoxidase assay of endotoxin-induced inflammation (United States Patent 6,022,699)

Hybrid Bacillus thuringiensis .delta.-endotoxins with novel broad-spectrum insecticidal activity (United States Patent 6,017,534)

Detection of endotoxin levels in liposomes, lipid bilayers and lipid complexes (United States Patent 6,015,716)

Compositions and methods for use in ischemia-reperfusion and endotoxin-related tissue injury (United States Patent 6,001,842)

Endotoxin-specific assay (United States Patent 5,998,389)

Process for remediating endotoxin-contaminated bulk non-ionic contrast media (United States Patent 5,972,225)

Vaccine and serum for endotoxin associated disease immunization and treatment, detoxified endotoxin, and bacterial mutant (United States Patent 5,961,985)

Bacillus thuringiensis .delta.-endotoxin (United States Patent 5,932,209)

Process for removing endotoxins (United States Patent 5,917,022)

Transgenic plants expressing lepidopteran-active .delta.-endotoxins (United States Patent 5,914,318)

Endotoxin stabilizing agent, endotoxin composition and method for assaying endotoxin (United States Patent 5,876,955)

Bacillus thuringiensis mutants which produce high yields of crystal delta-endotoxin (United States Patent 5,874,289)

Anti-endotoxin compounds (United States Patent 5,843,918)

Transformation vectors allowing expression of foreign polypeptide endotoxins in plants (United States Patent 5,843,898)

.beta.-Endotoxin expression in pseudomonas fluorescens (United States Patent 5,840,554)

Reagent for endotoxin assay and method for endotoxin assay using the same (United States Patent 5,840,510)

Use of interleukin-10 analogs for antagonists to treat endotoxin- or superantigen-induced toxicity (United States Patent 5,837,293)

Use of interleukin-10 (IL-10) to treat endotoxin- or superantigen-induced toxicity (United States Patent 5,833,976)

Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use (United States Patent 5,830,860)

Treatment of endotoxin-associated disorders with cationic peptides (United States Patent 5,789,377)

Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use (United States Patent 5,786,324)

Methods and kits for the detection of endotoxin (United States Patent 5,773,306)

Transformation vectors allowing expression of foreign polypeptide endotoxins from Bacillus thuringiensis in plants (United States Patent 5,767,372)

Endotoxins (United States Patent 5,760,181)

Anti-endotoxin compounds (United States Patent 5,756,718)

Process for inhibiting activity of endotoxin (United States Patent 5,750,500)

Process for the depletion or removal of endotoxins (United States Patent 5,747,663)

Endotoxin binding and neutralizing protein and uses thereof (United States Patent 5,747,455)

Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists (United States Patent 5,733,916)

Bacillus thuringiensis .alpha.-endotoxin fragments (United States Patent 5,710,020)

Reagent for endotoxin-specific assay (United States Patent 5,702,882)

Bacillus thuringiensis mutants which produce high yelds of crystal delta-endotoxin (United States Patent 5,698,440)

Reagent for endotoxin assay and method for endotoxin assay using the same (United States Patent 5,695,948)

Treatment of endotoxin-associated disorders with cationic peptides (United States Patent 5,688,767)

Method for protecting against endotoxin-induced shock using ornithine (United States Patent 5,686,493)

Methods and compositions useful in prophylaxis and therapy of endotoxin related conditions (United States Patent 5,674,855)

Water-soluble chitosan having low endotoxin concentration and methods for making and using the same (United States Patent 7,125,967)

Process for the depletion or removal of endotoxins (United States Patent 7,109,322)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.