PATENTS RELATED TO ENZYMES

Although Dr. Demchick also represents patent seekers with non-biochemical inventions, his Ph.D. is in microbiology (with a minor in biochemistry), his M.A. is in biology and his B.S. is in chemistry. Biochemistry has been a focus of his research and teaching. He especially loves dealing with patent searches and applications for involving biochemistry.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.

If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.

The following sampling is to give you some sense of the types of enzymes related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.

It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Manipulation of cellulose and/or .beta.-1,4,-glucan (United States Patent 7,154,026)

Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use (United States Patent 7,153,876)

5,6 -Trimethylenepyrimidin-4-one compounds (United States Patent 7,153,861)

Bioadhesive progressive hydration tablets (United States Patent 7,153,845)

Stabilization of antibodies or fragments thereof (United States Patent 7,153,819)

Amylolytic enzyme extracted from bacillus sp. A 7-7 (DSM 12368) and washing and cleaning agents containing this novel amylolytic enzyme (United States Patent 7,153,818)

Detergent tablet (United States Patent 7,153,817)

Hyaluronan synthase gene and uses thereof (United States Patent 7,153,677)

Transacylases of the paclitaxel biosynthetic pathway (United States Patent 7,153,676)

Process for the preparation of substituted carboxylic esters (United States Patent 7,153,675)

Nucleic acid molecules encoding enzymes having fructosyl polymerase activity (United States Patent 7,153,674)

Microfluidic devices and methods for performing temperature mediated reactions (United States Patent 7,153,673)

Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from Comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids (United States Patent 7,153,663)

Non-invasive enzyme screen for tissue remodelling-associated conditions (United States Patent 7,153,660)

Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence (United States Patent 7,153,655)

Electrostatic charge image developing toner, producing method therefor, image forming method and image forming apparatus utilizing the toner, construct and method for making the construct (United States Patent 7,153,622)

Methods for enlarging the diameter of an artery or vein in a human subject (United States Patent 7,153,505)

Comprehensive dietary supplement (United States Patent 7,153,503)

Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance (United States Patent 7,153,265)

Enzyme degradable curable resin compositions (United States Patent 7,151,124)

Inhibitors of Hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same (United States Patent 7,151,105)

Controlling proteolytic action in natural rubber latex (United States Patent 7,150,988)

Bacteriolytic complex, method for producing said complex and strain for carrying out said method (United States Patent 7,150,985)

Truncated aggrecanase molecules (United States Patent 7,150,983)

RNA detection assays (United States Patent 7,150,982)

Coffee mannanase (United States Patent 7,148,399)

Temperature sensitive mutant of bacteriophage T4 endonuclease VII (United States Patent 7,148,339)

Amino ceramide-like compounds and therapeutic methods of use (United States Patent 7,148,251)

Indoles as NAALADase inhibitors (United States Patent 7,148,250)

[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph (United States Patent 7,148,231)

Antibacterial agents (United States Patent 7,148,198)

Mitochondrial creatine kinase antibody (United States Patent 7,148,063)

Process for production of optically active 3-hydroxypentanenitrile (United States Patent 7,148,055)

Production of 3-hydroxycarboxylic acid using nitrilase (United States Patent 7,148,051)

Nucleic acid enzyme for RNA cleavage (United States Patent 7,148,044)

Submucosa gel compositions (United States Patent 7,147,871)

Process for preparing protease inhibitor intermediates (United States Patent 7,145,024)

Nucleic acid injected into hapatic vein lumen and delivered to primate liver (United States Patent 7,144,869)

Enhanced homologous recombination mediated by lambda recombination proteins (United States Patent 7,144,734)

Marine actinomycete taxon for drug and fermentation product discovery (United States Patent 7,144,723)

Protein and DNA thereof (United States Patent 7,144,720)

Oxidizing enzymes (United States Patent 7,144,717)

Recovery method for immobilized biocatalysts (United States Patent 7,144,716)

Diagnostics based on tetrazolium compounds (United States Patent 7,144,709)

Bioactive compositions derived from humulus lupulus (United States Patent 7,144,590)

Modified pertussis toxin (United States Patent 7,144,576)

Biological fluid analysis device (United States Patent 7,144,496)

Thermotolerant phytase for animal feed (United States Patent 7,141,717)

Enzymatic DNA molecules (United States Patent 7,141,665)

Genes encoding a nystatin polyketide synthase and their manipulation and utility (United States Patent 7,141,660)

Method for enhancing mutant enzyme activities in Gaucher disease (United States Patent 7,141,582)

Process for preparing optically active 3-hydroxypyrrolidine derivatives by enzymatic hydroxylation (United States Patent 7,141,412)

Hyaluronan synthase gene and uses thereof (United States Patent 7,141,409)

Candida kefyr cytosine deaminase (United States Patent 7,141,404)

Endo-beta-1,4-glucanases (United States Patent 7,141,403)

Process for the production of diglycerides (United States Patent 7,141,399)

Methods for recycling mRNA for linear cRNA amplification (United States Patent 7,141,398)

Microorganism culture medium (United States Patent 7,141,387)

Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors (United States Patent 7,141,385)

Cyclooxygenase-2 inhibitory withanolide compositions and method (United States Patent 7,141,253)

Use of bacterial phage associated lysing enzymes for treating upper respiratory illnesses (United States Patent 7,141,241)

Compositions for reducing UV-induced inhibition of collagen biosynthesis in human skin (United States Patent 7,141,238)

Computational method for designing enzymes for incorporation of non natural amino acids into proteins (United States Patent 7,139,665)

Thiolalkyl benzoic acid derivatives (United States Patent 7,138,543)

Method for producing a modified peptide (United States Patent 7,138,489)

3-Hydroxycarboxylic acid production and use in branched polymers (United States Patent 7,138,480)

Tetrahydroquinoline derivatives useful as serine protease inhibitors (United States Patent 7,138,412)

HIV integrase inhibitors, pharmaceutical compositions and methods for their use (United States Patent 7,138,408)

Modulators of DNA cytosine-5 methyltransferase and methods for use thereof (United States Patent 7,138,384)

Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof (United States Patent 7,138,264)

Endoglucanase enzyme NCE5 and cellulase preparations containing the same (United States Patent 7,138,263)

Polypeptides having sialytransferase activity (United States Patent 7,138,258)

Processes for preparing conjugated linoleic acid from conjugated linoleic acid esters (United States Patent 7,138,256)

Methods for diagnosing and treating dysautonomia and other dysautonomic conditions (United States Patent 7,138,123)

Use of bi-specific antibodies for pre-targeting diagnosis and therapy (United States Patent 7,138,103)

Process for the selective modification of carbohydrates by peroxidase catalyzed oxidation (United States Patent 7,138,035)

Method/process of determining a personal dietary supplement profile and recommending dietary supplements for an individual (United States Patent 7,136,820)

Mevalonate synthesis enzymes (United States Patent 7,135,622)

Expression in plants of starch binding domains and/or of protein-fusions containing starch binding domains (United States Patent 7,135,619)

Synthesis of enantiomerically pure amino-substituted fused bicyclic rings (United States Patent 7,135,570)

Peptide conjugated anti-cancer prodrugs (United States Patent 7,135,547)

HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use (United States Patent 7,135,482)

Composition for removal of odors and contaminants from textiles and method (United States Patent 7,135,449)

UDP-glucosyltransferases (United States Patent 7,135,326)

Short enzyme donor fragment (United States Patent 7,135,325)

Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester .alpha.-N-acetyl glucosimanidase (United States Patent 7,135,322)

Modified reductase and its gene (United States Patent 7,135,318)

Processes for the bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism (United States Patent 7,135,309)

Method of measuring homocysteine (United States Patent 7,135,306)

Catalase-inactivating compounds and the use thereof (United States Patent 7,135,299)

D-enzyme compositions and methods of their use (United States Patent 7,135,279)

Coated titanium dioxide particles (United States Patent 7,135,206)

Manipulation of the phenolic acid content and digestibility of plant cell walls by targeted expression of genes encoding cell wall degrading enzymes (United States Patent 7,132,589)

Aspartyl protease inhibitors (United States Patent 7,132,568)

Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals (United States Patent 7,132,536)

Bifunctional chelating agent (United States Patent 7,132,513)

Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension (United States Patent 7,132,437)

Inhibitors of 11-.beta.-hydroxy steroid dehydrogenase type 1 (United States Patent 7,132,436)

Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) (United States Patent 7,132,432)

Monocyclic derivatives as matrix metalloproteinase inhibitors (United States Patent 7,132,424)

Manipulation of cellulose and/or .beta.-1,4,-glucan (United States Patent 7,154,026)

Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use (United States Patent 7,153,876)

5,6 -Trimethylenepyrimidin-4-one compounds (United States Patent 7,153,861)

Bioadhesive progressive hydration tablets (United States Patent 7,153,845)

Stabilization of antibodies or fragments thereof (United States Patent 7,153,819)

Amylolytic enzyme extracted from bacillus sp. A 7-7 (DSM 12368) and washing and cleaning agents containing this novel amylolytic enzyme (United States Patent 7,153,818)

Detergent tablet (United States Patent 7,153,817)

Hyaluronan synthase gene and uses thereof (United States Patent 7,153,677)

Transacylases of the paclitaxel biosynthetic pathway (United States Patent 7,153,676)

Process for the preparation of substituted carboxylic esters (United States Patent 7,153,675)

Nucleic acid molecules encoding enzymes having fructosyl polymerase activity (United States Patent 7,153,674)

Microfluidic devices and methods for performing temperature mediated reactions (United States Patent 7,153,673)

Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from Comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids (United States Patent 7,153,663)

Non-invasive enzyme screen for tissue remodelling-associated conditions (United States Patent 7,153,660)

Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence (United States Patent 7,153,655)

Electrostatic charge image developing toner, producing method therefor, image forming method and image forming apparatus utilizing the toner, construct and method for making the construct (United States Patent 7,153,622)

Methods for enlarging the diameter of an artery or vein in a human subject (United States Patent 7,153,505)

Comprehensive dietary supplement (United States Patent 7,153,503)

Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance (United States Patent 7,153,265)

Enzyme degradable curable resin compositions (United States Patent 7,151,124)

Inhibitors of Hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same (United States Patent 7,151,105)

Controlling proteolytic action in natural rubber latex (United States Patent 7,150,988)

Bacteriolytic complex, method for producing said complex and strain for carrying out said method (United States Patent 7,150,985)

Truncated aggrecanase molecules (United States Patent 7,150,983)

RNA detection assays (United States Patent 7,150,982)

Coffee mannanase (United States Patent 7,148,399)

Temperature sensitive mutant of bacteriophage T4 endonuclease VII (United States Patent 7,148,339)

Amino ceramide-like compounds and therapeutic methods of use (United States Patent 7,148,251)

Indoles as NAALADase inhibitors (United States Patent 7,148,250)

[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph (United States Patent 7,148,231)

Antibacterial agents (United States Patent 7,148,198)

Mitochondrial creatine kinase antibody (United States Patent 7,148,063)

Process for production of optically active 3-hydroxypentanenitrile (United States Patent 7,148,055)

Production of 3-hydroxycarboxylic acid using nitrilase (United States Patent 7,148,051)

Nucleic acid enzyme for RNA cleavage (United States Patent 7,148,044)

Submucosa gel compositions (United States Patent 7,147,871)

Process for preparing protease inhibitor intermediates (United States Patent 7,145,024)

Nucleic acid injected into hapatic vein lumen and delivered to primate liver (United States Patent 7,144,869)

Enhanced homologous recombination mediated by lambda recombination proteins (United States Patent 7,144,734)

Marine actinomycete taxon for drug and fermentation product discovery (United States Patent 7,144,723)

Protein and DNA thereof (United States Patent 7,144,720)

Oxidizing enzymes (United States Patent 7,144,717)

Recovery method for immobilized biocatalysts (United States Patent 7,144,716)

Diagnostics based on tetrazolium compounds (United States Patent 7,144,709)

Bioactive compositions derived from humulus lupulus (United States Patent 7,144,590)

Modified pertussis toxin (United States Patent 7,144,576)

Biological fluid analysis device (United States Patent 7,144,496)

Thermotolerant phytase for animal feed (United States Patent 7,141,717)

Enzymatic DNA molecules (United States Patent 7,141,665)

Genes encoding a nystatin polyketide synthase and their manipulation and utility (United States Patent 7,141,660)

Method for enhancing mutant enzyme activities in Gaucher disease (United States Patent 7,141,582)

Process for preparing optically active 3-hydroxypyrrolidine derivatives by enzymatic hydroxylation (United States Patent 7,141,412)

Hyaluronan synthase gene and uses thereof (United States Patent 7,141,409)

Candida kefyr cytosine deaminase (United States Patent 7,141,404)

Endo-beta-1,4-glucanases (United States Patent 7,141,403)

Process for the production of diglycerides (United States Patent 7,141,399)

Methods for recycling mRNA for linear cRNA amplification (United States Patent 7,141,398)

Microorganism culture medium (United States Patent 7,141,387)

Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors (United States Patent 7,141,385)

Cyclooxygenase-2 inhibitory withanolide compositions and method (United States Patent 7,141,253)

Use of bacterial phage associated lysing enzymes for treating upper respiratory illnesses (United States Patent 7,141,241)

Compositions for reducing UV-induced inhibition of collagen biosynthesis in human skin (United States Patent 7,141,238)

Computational method for designing enzymes for incorporation of non natural amino acids into proteins (United States Patent 7,139,665)

Thiolalkyl benzoic acid derivatives (United States Patent 7,138,543)

Method for producing a modified peptide (United States Patent 7,138,489)

3-Hydroxycarboxylic acid production and use in branched polymers (United States Patent 7,138,480)

Tetrahydroquinoline derivatives useful as serine protease inhibitors (United States Patent 7,138,412)

HIV integrase inhibitors, pharmaceutical compositions and methods for their use (United States Patent 7,138,408)

Modulators of DNA cytosine-5 methyltransferase and methods for use thereof (United States Patent 7,138,384)

Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof (United States Patent 7,138,264)

Endoglucanase enzyme NCE5 and cellulase preparations containing the same (United States Patent 7,138,263)

Polypeptides having sialytransferase activity (United States Patent 7,138,258)

Processes for preparing conjugated linoleic acid from conjugated linoleic acid esters (United States Patent 7,138,256)

Methods for diagnosing and treating dysautonomia and other dysautonomic conditions (United States Patent 7,138,123)

Use of bi-specific antibodies for pre-targeting diagnosis and therapy (United States Patent 7,138,103)

Process for the selective modification of carbohydrates by peroxidase catalyzed oxidation (United States Patent 7,138,035)

Method/process of determining a personal dietary supplement profile and recommending dietary supplements for an individual (United States Patent 7,136,820)

Mevalonate synthesis enzymes (United States Patent 7,135,622)

Expression in plants of starch binding domains and/or of protein-fusions containing starch binding domains (United States Patent 7,135,619)

Synthesis of enantiomerically pure amino-substituted fused bicyclic rings (United States Patent 7,135,570)

Peptide conjugated anti-cancer prodrugs (United States Patent 7,135,547)

HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use (United States Patent 7,135,482)

Composition for removal of odors and contaminants from textiles and method (United States Patent 7,135,449)

UDP-glucosyltransferases (United States Patent 7,135,326)

Short enzyme donor fragment (United States Patent 7,135,325)

Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester .alpha.-N-acetyl glucosimanidase (United States Patent 7,135,322)

Modified reductase and its gene (United States Patent 7,135,318)

Processes for the bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism (United States Patent 7,135,309)

Method of measuring homocysteine (United States Patent 7,135,306)

Catalase-inactivating compounds and the use thereof (United States Patent 7,135,299)

D-enzyme compositions and methods of their use (United States Patent 7,135,279)

Coated titanium dioxide particles (United States Patent 7,135,206)

Manipulation of the phenolic acid content and digestibility of plant cell walls by targeted expression of genes encoding cell wall degrading enzymes (United States Patent 7,132,589)

Aspartyl protease inhibitors (United States Patent 7,132,568)

Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals (United States Patent 7,132,536)

Bifunctional chelating agent (United States Patent 7,132,513)

Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension (United States Patent 7,132,437)

Inhibitors of 11-.beta.-hydroxy steroid dehydrogenase type 1 (United States Patent 7,132,436)

Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) (United States Patent 7,132,432)

Monocyclic derivatives as matrix metalloproteinase inhibitors (United States Patent 7,132,424)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.