PATENTS RELATED TO EXOTOXINS

Professor Demchick's Patent Services

Paul H. Demchick, United States Registered Patent Agent
(United States Patent and Trademark Office Registration 52,808)

PATENTS RELATED TO EXOTOXINS

Although Dr. Demchick also represents patent seekers with non-microbiological inventions, his doctorate is in microbiology. Microbiology has been the primary focus of his research and teaching. He especially loves dealing with patent searches and applications for involving microbiology.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.
If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.
The following sampling is to give you some sense of the types of exotoxins related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.
It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Modified pertussis toxin (United States Patent 7,144,576)
Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins (United States Patent 7,060,277)
Adjuvant for transcutaneous immunization (United States Patent 7,037,499)
Inhibition of exoprotein production in non-absorbent articles uisng aromatic compositions (United States Patent 7,022,333)
Chimeric toxins for targeted therapy (United States Patent 6,933,271)
Method for inactivating gonadotrophs (United States Patent 6,924,268)
Fc.epsilon.PE chimeric protein for targeted treatment of allergy responses, a method for its production and pharmaceutical compositions containing the same (United States Patent 6,919,079)
Methods for the inhibition of exoprotein production from Gram positive bacteria (United States Patent 6,911,480)
Anionic polymers as toxin binders and antibacterial agents (United States Patent 6,890,523)
Disulfide conjugated cell toxins and methods of making and using them (United States Patent 6,881,718)
Peptide repeat immunogens (United States Patent 6,838,553)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,692,746)
Vaccine against Staphylococcus intoxication (United States Patent 6,632,640)
Immunity against pasteurella haemolytica leukotoxin (United States Patent 6,610,307)
Inhibition of exoprotein production in non-absorbent articles using isoprenoid compositions (United States Patent 6,596,290)
Isoprenoid compositions for the inhibition of exoprotein production from gram positive bacteria (United States Patent 6,534,548)
Pseudomonas exotoxin-myelin basic protein chimeric proteins (United States Patent 6,531,133)
IL-13 receptor specific chimeric proteins and uses thereof (United States Patent 6,518,061)
Anionic polymers as toxin binders and antibacterial agent (United States Patent 6,517,827)
Anionic polymers as toxin binders and antibacterial agents (United States Patent 6,517,826)
Protease-activatable pseudomonas exotoxin A-like proproteins (United States Patent 6,426,075)
Polynucleotides encoding protease-activatable pseudomonas exotoxin a-like proproteins (United States Patent 6,423,513)
Anionic polymers as toxin binders (United States Patent 6,419,914)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,338,845)
Hormone-recombinant toxin compounds and methods for using same (United States Patent 6,326,467)
Anionic polymers as toxin binders and antibacterial agents (United States Patent 6,290,946)
Anionic polymers as toxin binders (United States Patent 6,270,755)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,221,351)
Septicemia prevention and treatment system (United States Patent 6,193,681)
Methods of cancer diagnosis using a chimeric toxin (United States Patent 6,140,066)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,126,945)
Treatment of gastrointestinal ulcers or gastritis caused by microbial infection (United States Patent 6,117,868)
GnRH analogs for destroying gonadotrophs (United States Patent 6,103,881)
Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin (United States Patent 6,099,842)
Nucleic acids encoding immunotoxins containing a disulfide-stabilized antibody fragment replacing half or more of domain IB of pseudomonas exotoxin, and methods of use of the encoded immunotoxins (United States Patent 6,074,644)
Tampon packaging system (United States Patent 6,068,899)
Method for detection of Pseudomonas aeruginosa using polymerase chain reaction (United States Patent 6,048,688)
Hybrid molecules having translocation region and cell-binding region (United States Patent 6,022,950)
Method of treating symptoms of microbial infection or sepsis (United States Patent 6,011,030)
Adjuvant for transcutaneous immunization (United States Patent 5,980,898)
Immunotoxin containing a disulfide-stabilized antibody fragment joined to a Pseudomonas exotoxin that does not require proteolytic activation (United States Patent 5,980,895)
Method of treating microbial infections (United States Patent 5,972,933)
Modified pseudomonas exotoxin PE.sub.40 (United States Patent 5,912,322)
Mutagenized DNA molecules encoding modified subunit a of Cholera-toxin (United States Patent 5,874,287)
Recombinant pseudomonas exotoxin with increased activity (United States Patent 5,854,044)
Recombinant pseudomonas exotoxin with increased activity (United States Patent 5,821,238)
Tampon and method of making same (United States Patent 5,817,047)
Hormone-nuclease compounds and method for regulating hormone related diseases (United States Patent 5,786,457)
DNA encoding pertussis toxin muteins (United States Patent 5,773,600)
Modified cholera toxin based on mutagenized subunit A (United States Patent 5,770,203)
Prevention of toxin production using absorbent products (United States Patent 5,753,252)
Method for treating cancer (United States Patent 5,707,964)
Target-specific, cytotoxic, recombinant pseudomonas exotoxin (United States Patent 5,705,163)
Psuedomonas exotoxins of low animal toxicity and high cytocidal activity (United States Patent 5,705,156)
Inhibition of exoprotein using amide compositions in absorbent article (United States Patent 5,685,872)
Hybrid molecules having translocation region and cell-binding region (United States Patent 5,668,255)
Method for inactivating gonadotrophs (United States Patent 5,631,229)
Modified pseudomonas exotoxin PE.sub.40 (United States Patent 5,621,078)
Inhibition of exoprotein using amine compositions in absorbent article and method thereof (United States Patent 5,618,554)
Inhibition of exoprotein in absorbent article (United States Patent 5,612,045)
Recombinant pseudomonas exotoxin with increased activity (United States Patent 5,602,095)
Additives to feminine products (United States Patent 5,547,985)
Method for suppressing the viscosity of bioinsecticide slurries and related slurries (United States Patent 5,538,723)
Pseudomonas exotoxins (PE) and conjugates thereof having lower animal toxicity with high cytocidal activity through substitution of positively charged amino acids (United States Patent 5,512,658)
Hormone-toxin conjugate compounds (United States Patent 5,492,893)
Method for sterilizing animals using hormone-toxin conjugate compounds (United States Patent 5,488,036)
P. exotoxin fusio proteins have COOHG220101al alterations which increase cytotoxicity (United States Patent 5,458,878)
Prevention of toxin production using absorbent products (United States Patent 5,389,374)
GnRH analogs for destroying gonadotrophs (United States Patent 5,378,688)
Use of a modified soluble Pseudomonas exotoxin A in immunoconjugates (United States Patent 4,933,288)
Manufacture and use of tagetitoxin (United States Patent 4,874,706)
Monoclonal antibody against ovarian cancer cells (OVB-3) (United States Patent 4,806,494)
Pseudomonas aeruginosa exotoxin A antibodies, their preparation and use (United States Patent 4,677,070)
Compositions for combatting toxaemia (United States Patent 4,626,536)
Pseudomonas exotoxin conjugate immunotoxins (United States Patent 4,545,985)
Method for producing pertussis toxoid (United States Patent 4,455,297)
Oil separation and heat recovery system (United States Patent 4,452,671)
Synergistic insecticidal compositions containing .beta.-exotoxin (United States Patent 4,016,265)
Synergistic acaricide compositions (United States Patent 3,944,664)
Modified pertussis toxin (United States Patent 7,144,576)
Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins (United States Patent 7,060,277)
Adjuvant for transcutaneous immunization (United States Patent 7,037,499)
Inhibition of exoprotein production in non-absorbent articles uisng aromatic compositions (United States Patent 7,022,333)
Chimeric toxins for targeted therapy (United States Patent 6,933,271)
Method for inactivating gonadotrophs (United States Patent 6,924,268)
Fc.epsilon.PE chimeric protein for targeted treatment of allergy responses, a method for its production and pharmaceutical compositions containing the same (United States Patent 6,919,079)
Methods for the inhibition of exoprotein production from Gram positive bacteria (United States Patent 6,911,480)
Anionic polymers as toxin binders and antibacterial agents (United States Patent 6,890,523)
Disulfide conjugated cell toxins and methods of making and using them (United States Patent 6,881,718)
Peptide repeat immunogens (United States Patent 6,838,553)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,692,746)
Vaccine against Staphylococcus intoxication (United States Patent 6,632,640)
Immunity against pasteurella haemolytica leukotoxin (United States Patent 6,610,307)
Inhibition of exoprotein production in non-absorbent articles using isoprenoid compositions (United States Patent 6,596,290)
Isoprenoid compositions for the inhibition of exoprotein production from gram positive bacteria (United States Patent 6,534,548)
Pseudomonas exotoxin-myelin basic protein chimeric proteins (United States Patent 6,531,133)
IL-13 receptor specific chimeric proteins and uses thereof (United States Patent 6,518,061)
Anionic polymers as toxin binders and antibacterial agent (United States Patent 6,517,827)
Anionic polymers as toxin binders and antibacterial agents (United States Patent 6,517,826)
Protease-activatable pseudomonas exotoxin A-like proproteins (United States Patent 6,426,075)
Polynucleotides encoding protease-activatable pseudomonas exotoxin a-like proproteins (United States Patent 6,423,513)
Anionic polymers as toxin binders (United States Patent 6,419,914)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,338,845)
Hormone-recombinant toxin compounds and methods for using same (United States Patent 6,326,467)
Anionic polymers as toxin binders and antibacterial agents (United States Patent 6,290,946)
Anionic polymers as toxin binders (United States Patent 6,270,755)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,221,351)
Septicemia prevention and treatment system (United States Patent 6,193,681)
Methods of cancer diagnosis using a chimeric toxin (United States Patent 6,140,066)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,126,945)
Treatment of gastrointestinal ulcers or gastritis caused by microbial infection (United States Patent 6,117,868)
GnRH analogs for destroying gonadotrophs (United States Patent 6,103,881)
Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin (United States Patent 6,099,842)
Nucleic acids encoding immunotoxins containing a disulfide-stabilized antibody fragment replacing half or more of domain IB of pseudomonas exotoxin, and methods of use of the encoded immunotoxins (United States Patent 6,074,644)
Tampon packaging system (United States Patent 6,068,899)
Method for detection of Pseudomonas aeruginosa using polymerase chain reaction (United States Patent 6,048,688)
Hybrid molecules having translocation region and cell-binding region (United States Patent 6,022,950)
Method of treating symptoms of microbial infection or sepsis (United States Patent 6,011,030)
Adjuvant for transcutaneous immunization (United States Patent 5,980,898)
Immunotoxin containing a disulfide-stabilized antibody fragment joined to a Pseudomonas exotoxin that does not require proteolytic activation (United States Patent 5,980,895)
Method of treating microbial infections (United States Patent 5,972,933)
Modified pseudomonas exotoxin PE.sub.40 (United States Patent 5,912,322)
Mutagenized DNA molecules encoding modified subunit a of Cholera-toxin (United States Patent 5,874,287)
Recombinant pseudomonas exotoxin with increased activity (United States Patent 5,854,044)
Recombinant pseudomonas exotoxin with increased activity (United States Patent 5,821,238)
Tampon and method of making same (United States Patent 5,817,047)
Hormone-nuclease compounds and method for regulating hormone related diseases (United States Patent 5,786,457)
DNA encoding pertussis toxin muteins (United States Patent 5,773,600)
Modified cholera toxin based on mutagenized subunit A (United States Patent 5,770,203)
Prevention of toxin production using absorbent products (United States Patent 5,753,252)
Method for treating cancer (United States Patent 5,707,964)
Target-specific, cytotoxic, recombinant pseudomonas exotoxin (United States Patent 5,705,163)
Psuedomonas exotoxins of low animal toxicity and high cytocidal activity (United States Patent 5,705,156)
Inhibition of exoprotein using amide compositions in absorbent article (United States Patent 5,685,872)
Hybrid molecules having translocation region and cell-binding region (United States Patent 5,668,255)
Method for inactivating gonadotrophs (United States Patent 5,631,229)
Modified pseudomonas exotoxin PE.sub.40 (United States Patent 5,621,078)
Inhibition of exoprotein using amine compositions in absorbent article and method thereof (United States Patent 5,618,554)
Inhibition of exoprotein in absorbent article (United States Patent 5,612,045)
Recombinant pseudomonas exotoxin with increased activity (United States Patent 5,602,095)
Additives to feminine products (United States Patent 5,547,985)
Method for suppressing the viscosity of bioinsecticide slurries and related slurries (United States Patent 5,538,723)
Pseudomonas exotoxins (PE) and conjugates thereof having lower animal toxicity with high cytocidal activity through substitution of positively charged amino acids (United States Patent 5,512,658)
Hormone-toxin conjugate compounds (United States Patent 5,492,893)
Method for sterilizing animals using hormone-toxin conjugate compounds (United States Patent 5,488,036)
P. exotoxin fusio proteins have COOHG220101al alterations which increase cytotoxicity (United States Patent 5,458,878)
Prevention of toxin production using absorbent products (United States Patent 5,389,374)
GnRH analogs for destroying gonadotrophs (United States Patent 5,378,688)
Use of a modified soluble Pseudomonas exotoxin A in immunoconjugates (United States Patent 4,933,288)
Manufacture and use of tagetitoxin (United States Patent 4,874,706)
Monoclonal antibody against ovarian cancer cells (OVB-3) (United States Patent 4,806,494)
Pseudomonas aeruginosa exotoxin A antibodies, their preparation and use (United States Patent 4,677,070)
Compositions for combatting toxaemia (United States Patent 4,626,536)
Pseudomonas exotoxin conjugate immunotoxins (United States Patent 4,545,985)
Method for producing pertussis toxoid (United States Patent 4,455,297)
Oil separation and heat recovery system (United States Patent 4,452,671)
Synergistic insecticidal compositions containing .beta.-exotoxin (United States Patent 4,016,265)
Synergistic acaricide compositions (United States Patent 3,944,664)
Modified pertussis toxin (United States Patent 7,144,576)
Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins (United States Patent 7,060,277)
Adjuvant for transcutaneous immunization (United States Patent 7,037,499)
Inhibition of exoprotein production in non-absorbent articles uisng aromatic compositions (United States Patent 7,022,333)
Chimeric toxins for targeted therapy (United States Patent 6,933,271)
Method for inactivating gonadotrophs (United States Patent 6,924,268)
Fc.epsilon.PE chimeric protein for targeted treatment of allergy responses, a method for its production and pharmaceutical compositions containing the same (United States Patent 6,919,079)
Methods for the inhibition of exoprotein production from Gram positive bacteria (United States Patent 6,911,480)
Anionic polymers as toxin binders and antibacterial agents (United States Patent 6,890,523)
Disulfide conjugated cell toxins and methods of making and using them (United States Patent 6,881,718)
Peptide repeat immunogens (United States Patent 6,838,553)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,692,746)
Vaccine against Staphylococcus intoxication (United States Patent 6,632,640)
Immunity against pasteurella haemolytica leukotoxin (United States Patent 6,610,307)
Inhibition of exoprotein production in non-absorbent articles using isoprenoid compositions (United States Patent 6,596,290)
Isoprenoid compositions for the inhibition of exoprotein production from gram positive bacteria (United States Patent 6,534,548)
Pseudomonas exotoxin-myelin basic protein chimeric proteins (United States Patent 6,531,133)
IL-13 receptor specific chimeric proteins and uses thereof (United States Patent 6,518,061)
Anionic polymers as toxin binders and antibacterial agent (United States Patent 6,517,827)
Anionic polymers as toxin binders and antibacterial agents (United States Patent 6,517,826)
Protease-activatable pseudomonas exotoxin A-like proproteins (United States Patent 6,426,075)
Polynucleotides encoding protease-activatable pseudomonas exotoxin a-like proproteins (United States Patent 6,423,513)
Anionic polymers as toxin binders (United States Patent 6,419,914)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,338,845)
Hormone-recombinant toxin compounds and methods for using same (United States Patent 6,326,467)
Anionic polymers as toxin binders and antibacterial agents (United States Patent 6,290,946)
Anionic polymers as toxin binders (United States Patent 6,270,755)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,221,351)
Septicemia prevention and treatment system (United States Patent 6,193,681)
Methods of cancer diagnosis using a chimeric toxin (United States Patent 6,140,066)
Tumor killing effects of enterotoxins, superantigens, and related compounds (United States Patent 6,126,945)
Treatment of gastrointestinal ulcers or gastritis caused by microbial infection (United States Patent 6,117,868)
GnRH analogs for destroying gonadotrophs (United States Patent 6,103,881)
Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin (United States Patent 6,099,842)
Nucleic acids encoding immunotoxins containing a disulfide-stabilized antibody fragment replacing half or more of domain IB of pseudomonas exotoxin, and methods of use of the encoded immunotoxins (United States Patent 6,074,644)
Tampon packaging system (United States Patent 6,068,899)
Method for detection of Pseudomonas aeruginosa using polymerase chain reaction (United States Patent 6,048,688)
Hybrid molecules having translocation region and cell-binding region (United States Patent 6,022,950)
Method of treating symptoms of microbial infection or sepsis (United States Patent 6,011,030)
Adjuvant for transcutaneous immunization (United States Patent 5,980,898)
Immunotoxin containing a disulfide-stabilized antibody fragment joined to a Pseudomonas exotoxin that does not require proteolytic activation (United States Patent 5,980,895)
Method of treating microbial infections (United States Patent 5,972,933)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.