PATENTS RELATED TO GRAM NEGATIVE BACTERIA

Professor Demchick's Patent Services

Paul H. Demchick, United States Registered Patent Agent
(United States Patent and Trademark Office Registration 52,808)

PATENTS RELATED TO GRAM NEGATIVE BACTERIA

Although Dr. Demchick also represents patent seekers with non-microbiological inventions, his doctorate is in microbiology. Microbiology has been the primary focus of his research and teaching. He especially loves dealing with patent searches and applications for involving microbiology.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.
If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.
The following sampling is to give you some sense of the types of gram negative bacteria related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.
It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Polypeptides obtained from gram negative microbes (United States Patent 7,138,124)
Compositions and methods for eliciting an immune response to gram-negative bacterial infections (United States Patent 7,135,175)
Production or aromatic carotenoids in gram negative bacteria (United States Patent 7,132,257)
Compositions and methods for eliciting an immune response to gram-negative bacterial infections (United States Patent 7,132,101)
Vaccine against Gram-negative bacterial infections (United States Patent 7,025,963)
Vaccine against Gram-negative bacterial infections (United States Patent 7,018,636)
Mutants of gram negative mucosal bacteria and application thereof in vaccines (United States Patent 7,011,836)
Non-toxic mutants of pathogenic gram-negative bacteria (United States Patent 7,005,129)
Method for detecting a gram-negative bacterial autoinducer molecule (United States Patent 6,979,696)
Method for detecting a gram-negative bacterial autoinducer molecule (United States Patent 6,958,219)
Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases (United States Patent 6,951,652)
Preparation and uses of los-depleted outer membrane proteins of gram-negative cocci (United States Patent 6,921,537)
Non-toxic mutants of pathogenic gram-negative bacteria (United States Patent 6,887,483)
Conjugate vaccine against gram-negative bacterial infections (United States Patent 6,872,398)
Antibodies raised against immunogenic conjugates of gram-negative bacterial autoinducer molecules (United States Patent 6,713,059)
Method for screening for inhibitors and activators of type III secretion machinery in gram-negative bacteria (United States Patent 6,696,249)
Invaplex from gram negative bacteria, method of purification and methods of use (United States Patent 6,680,374)
Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria (United States Patent 6,645,503)
Live vaccines against gram-negative pathogens, expressing heterologous O-antigens (United States Patent 6,613,321)
Bacterial gene and method of treating a gram negative bacterial infection (United States Patent 6,570,006)
Vaccine against gram negative bacteria (United States Patent 6,558,677)
Method for killing gram-negative bacteria with biologically active peptides from functional domains of bacterial/permeability-increasing protein (United States Patent 6,495,516)
LPS with reduced toxicity from genetically modified gram negative bacteria (United States Patent 6,482,807)
Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria (United States Patent 6,413,529)
Immunogenic conjugates of Gram-negative bacterial autoinducer molecules (United States Patent 6,395,282)
Preparation and uses of LOS-depleted outer membrane proteins of gram-negative cocci (United States Patent 6,355,253)
Gram negative antibacterial composition (United States Patent 6,287,617)
Use of purified invaplex from gram negative bacteria as a vaccine (United States Patent 6,277,379)
Methods for controlling gram negative bacteria in mammals with bicyclo spiroether compounds (United States Patent 6,271,256)
Gram negative coccoid bacterium okadaella gastrococcus (United States Patent 6,261,824)
Invaplex from gram negative bacteria, method of purification and methods of use (United States Patent 6,245,892)
Liquid antimicrobial cleansing compositions which provide residual benefit versus gram negative bacteria (United States Patent 6,214,363)
Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria (United States Patent 6,197,315)
Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic (United States Patent 6,140,306)
Method for screening for inhibitors and activators of type III secretion machinery in gram-negative bacteria (United States Patent 6,136,542)
Methods for controlling gram negative bacteria in mammals (United States Patent 6,017,950)
Mild, rinse-off antimicrobial liquid cleansing compositions which provide residual benefit versus gram negative bacteria (United States Patent 5,968,539)
Encapsulated high-concentration lipid a compositions as immunogenic agents to produce human antibodies to prevent or treat gram-negative bacterial infections (United States Patent 5,888,519)
Methods for detection of gram negative bacteria (United States Patent 5,869,272)
Secretion of outer membrane proteins of gram-negative bacteria by means of gram-positive host organisms (United States Patent 5,858,727)
Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use (United States Patent 5,830,860)
Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use (United States Patent 5,786,324)
Pharmaceutical agents for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria (United States Patent 5,750,535)
Gram-negative alkaliphilic microorganisms (United States Patent 5,733,767)
Oral vaccine against gram negative bacterial infection (United States Patent 5,730,989)
Gram-negative alkaliphilic microorganisms (United States Patent 5,719,047)
Method for treating gram negative bacterial infections in humans (United States Patent 5,698,198)
Method of preparing gram-negative bacterial vaccines (United States Patent 5,616,328)
Gram-negative alkaliphilic microorganisms (United States Patent 5,571,716)
Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic (United States Patent 5,523,288)
Gram-negative alkaliphilic microorganisms (United States Patent 5,514,575)
Method for treating gram negative bacterial infections in humans (United States Patent 5,484,591)
Gram-negative alkaliphilic microorganisms (United States Patent 5,459,062)
Human monoclonal antibody to lipid A of gram negative bacteria (United States Patent 5,426,046)
Method for detection of gram-negative bacterial liposaccharides in biological fluids (United States Patent 5,356,778)
DNA encoding polypeptides with activity against gram-positive and gram-negative bacteria (United States Patent 5,344,765)
Signal peptide, DNA sequences coding for the latter, expression vectors carrying one of these sequences, gram-negative bacteria transformed by these vectors, and process for the periplasmic production of a polypeptide (United States Patent 5,284,768)
Process for producing proteins using gram negative host cells (United States Patent 5,268,270)
Method for detection of gram-negative bacterial lipopolysaccharides in biological fluids (United States Patent 5,198,339)
Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria (United States Patent 5,179,018)
Detection and monitoring of chronic and gram-negative infection (United States Patent 5,179,001)
Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria (United States Patent 5,166,321)
Method to export gene products to the growth medium of gram negative bacteria (United States Patent 5,156,959)
Gram-positive and gram-negative antibacterial compounds from the microorganism, Janthinobacterium lividum (United States Patent 5,081,225)
Detection of endotoxins of gram negative bacteria (United States Patent 5,059,527)
Process for removing bacterial endotoxin from gram-negative polysaccharides (United States Patent 5,045,456)
Process for removing bacterial endotoxin from gram-negative polysaccharides (United States Patent 5,039,610)
Process for removing bacterial endotoxin from gram-negative polysaccharides (United States Patent 5,019,502)
Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria (United States Patent 4,918,163)
Method of preventing diseases caused by gram-negative endotoxin in mammals (United States Patent 4,918,061)
Process for preparing veterinary acellular vaccines against gram-negative nonenteric pathogenic bacilli (United States Patent 4,877,613)
Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production (United States Patent 4,834,975)
Method of decreasing lung damage in a host following the onset of gram negative septicemia/endotoxemia (United States Patent 4,829,054)
Co-vaccination using non-O-carbohydrate side-chain gram-negative bacteria preparation (United States Patent 4,789,544)
Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL) (United States Patent 4,717,658)
Class II mobilizable gram-negative plasmid (United States Patent 4,680,264)
Vaccines for gram-negative bacteria (United States Patent 4,663,160)
DNA transfer vector for gram-negative bacteria (United States Patent 4,626,504)
Broad host range DNA cloning system for gram-negative bacteria (United States Patent 4,590,163)
Process for rapidly differentiating between gram-negative and gram-positive microorganisms (United States Patent 4,525,453)
Molecular cloning vectors for use in gram-negative bacteria (United States Patent 4,508,827)
Bacterial toxoids and gram-negative immune globulin therefrom (United States Patent 4,488,991)
Bacterial toxoids and gram-negative immune globulin therefrom (United States Patent 4,428,931)
Pharmaceutical compositions endowed with an antibacterial activity and their use in the treatment of infections due to gram-positive and gram-negative pathogens (United States Patent 4,386,070)
Method for enumeration of oral gram-negative bacteria (United States Patent 4,379,135)
Low protein degradation product basal medium for identification of non-fermentative gram-negative bacilli and other microorganisms (United States Patent 4,335,205)
Method for distinguishing gram positive and gram negative microbes (United States Patent 4,126,516)
Identification of non-fermentative gram-negative bacteria (United States Patent 4,048,016)
Certain quaternary ammonium salts used to control gram-negative bacteria (United States Patent 4,015,013)
Antibacterial agents for Gram-negative bacteria (United States Patent 4,012,359)
Polypeptides obtained from gram negative microbes (United States Patent 7,138,124)
Compositions and methods for eliciting an immune response to gram-negative bacterial infections (United States Patent 7,135,175)
Production or aromatic carotenoids in gram negative bacteria (United States Patent 7,132,257)
Compositions and methods for eliciting an immune response to gram-negative bacterial infections (United States Patent 7,132,101)
Vaccine against Gram-negative bacterial infections (United States Patent 7,025,963)
Vaccine against Gram-negative bacterial infections (United States Patent 7,018,636)
Mutants of gram negative mucosal bacteria and application thereof in vaccines (United States Patent 7,011,836)
Non-toxic mutants of pathogenic gram-negative bacteria (United States Patent 7,005,129)
Method for detecting a gram-negative bacterial autoinducer molecule (United States Patent 6,979,696)
Method for detecting a gram-negative bacterial autoinducer molecule (United States Patent 6,958,219)
Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases (United States Patent 6,951,652)
Preparation and uses of los-depleted outer membrane proteins of gram-negative cocci (United States Patent 6,921,537)
Non-toxic mutants of pathogenic gram-negative bacteria (United States Patent 6,887,483)
Conjugate vaccine against gram-negative bacterial infections (United States Patent 6,872,398)
Antibodies raised against immunogenic conjugates of gram-negative bacterial autoinducer molecules (United States Patent 6,713,059)
Method for screening for inhibitors and activators of type III secretion machinery in gram-negative bacteria (United States Patent 6,696,249)
Invaplex from gram negative bacteria, method of purification and methods of use (United States Patent 6,680,374)
Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria (United States Patent 6,645,503)
Live vaccines against gram-negative pathogens, expressing heterologous O-antigens (United States Patent 6,613,321)
Bacterial gene and method of treating a gram negative bacterial infection (United States Patent 6,570,006)
Vaccine against gram negative bacteria (United States Patent 6,558,677)
Method for killing gram-negative bacteria with biologically active peptides from functional domains of bacterial/permeability-increasing protein (United States Patent 6,495,516)
LPS with reduced toxicity from genetically modified gram negative bacteria (United States Patent 6,482,807)
Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria (United States Patent 6,413,529)
Immunogenic conjugates of Gram-negative bacterial autoinducer molecules (United States Patent 6,395,282)
Preparation and uses of LOS-depleted outer membrane proteins of gram-negative cocci (United States Patent 6,355,253)
Gram negative antibacterial composition (United States Patent 6,287,617)
Use of purified invaplex from gram negative bacteria as a vaccine (United States Patent 6,277,379)
Methods for controlling gram negative bacteria in mammals with bicyclo spiroether compounds (United States Patent 6,271,256)
Gram negative coccoid bacterium okadaella gastrococcus (United States Patent 6,261,824)
Invaplex from gram negative bacteria, method of purification and methods of use (United States Patent 6,245,892)
Liquid antimicrobial cleansing compositions which provide residual benefit versus gram negative bacteria (United States Patent 6,214,363)
Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria (United States Patent 6,197,315)
Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic (United States Patent 6,140,306)
Method for screening for inhibitors and activators of type III secretion machinery in gram-negative bacteria (United States Patent 6,136,542)
Methods for controlling gram negative bacteria in mammals (United States Patent 6,017,950)
Mild, rinse-off antimicrobial liquid cleansing compositions which provide residual benefit versus gram negative bacteria (United States Patent 5,968,539)
Encapsulated high-concentration lipid a compositions as immunogenic agents to produce human antibodies to prevent or treat gram-negative bacterial infections (United States Patent 5,888,519)
Methods for detection of gram negative bacteria (United States Patent 5,869,272)
Secretion of outer membrane proteins of gram-negative bacteria by means of gram-positive host organisms (United States Patent 5,858,727)
Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use (United States Patent 5,830,860)
Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use (United States Patent 5,786,324)
Pharmaceutical agents for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria (United States Patent 5,750,535)
Gram-negative alkaliphilic microorganisms (United States Patent 5,733,767)
Oral vaccine against gram negative bacterial infection (United States Patent 5,730,989)
Gram-negative alkaliphilic microorganisms (United States Patent 5,719,047)
Method for treating gram negative bacterial infections in humans (United States Patent 5,698,198)
Method of preparing gram-negative bacterial vaccines (United States Patent 5,616,328)
Gram-negative alkaliphilic microorganisms (United States Patent 5,571,716)
Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic (United States Patent 5,523,288)
Gram-negative alkaliphilic microorganisms (United States Patent 5,514,575)
Method for treating gram negative bacterial infections in humans (United States Patent 5,484,591)
Gram-negative alkaliphilic microorganisms (United States Patent 5,459,062)
Human monoclonal antibody to lipid A of gram negative bacteria (United States Patent 5,426,046)
Method for detection of gram-negative bacterial liposaccharides in biological fluids (United States Patent 5,356,778)
DNA encoding polypeptides with activity against gram-positive and gram-negative bacteria (United States Patent 5,344,765)
Signal peptide, DNA sequences coding for the latter, expression vectors carrying one of these sequences, gram-negative bacteria transformed by these vectors, and process for the periplasmic production of a polypeptide (United States Patent 5,284,768)
Process for producing proteins using gram negative host cells (United States Patent 5,268,270)
Method for detection of gram-negative bacterial lipopolysaccharides in biological fluids (United States Patent 5,198,339)
Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria (United States Patent 5,179,018)
Detection and monitoring of chronic and gram-negative infection (United States Patent 5,179,001)
Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria (United States Patent 5,166,321)
Method to export gene products to the growth medium of gram negative bacteria (United States Patent 5,156,959)
Gram-positive and gram-negative antibacterial compounds from the microorganism, Janthinobacterium lividum (United States Patent 5,081,225)
Detection of endotoxins of gram negative bacteria (United States Patent 5,059,527)
Process for removing bacterial endotoxin from gram-negative polysaccharides (United States Patent 5,045,456)
Process for removing bacterial endotoxin from gram-negative polysaccharides (United States Patent 5,039,610)
Process for removing bacterial endotoxin from gram-negative polysaccharides (United States Patent 5,019,502)
Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria (United States Patent 4,918,163)
Method of preventing diseases caused by gram-negative endotoxin in mammals (United States Patent 4,918,061)
Process for preparing veterinary acellular vaccines against gram-negative nonenteric pathogenic bacilli (United States Patent 4,877,613)
Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production (United States Patent 4,834,975)
Method of decreasing lung damage in a host following the onset of gram negative septicemia/endotoxemia (United States Patent 4,829,054)
Co-vaccination using non-O-carbohydrate side-chain gram-negative bacteria preparation (United States Patent 4,789,544)
Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL) (United States Patent 4,717,658)
Class II mobilizable gram-negative plasmid (United States Patent 4,680,264)
Vaccines for gram-negative bacteria (United States Patent 4,663,160)
DNA transfer vector for gram-negative bacteria (United States Patent 4,626,504)
Broad host range DNA cloning system for gram-negative bacteria (United States Patent 4,590,163)
Process for rapidly differentiating between gram-negative and gram-positive microorganisms (United States Patent 4,525,453)
Molecular cloning vectors for use in gram-negative bacteria (United States Patent 4,508,827)
Bacterial toxoids and gram-negative immune globulin therefrom (United States Patent 4,488,991)
Bacterial toxoids and gram-negative immune globulin therefrom (United States Patent 4,428,931)
Pharmaceutical compositions endowed with an antibacterial activity and their use in the treatment of infections due to gram-positive and gram-negative pathogens (United States Patent 4,386,070)
Method for enumeration of oral gram-negative bacteria (United States Patent 4,379,135)
Low protein degradation product basal medium for identification of non-fermentative gram-negative bacilli and other microorganisms (United States Patent 4,335,205)
Method for distinguishing gram positive and gram negative microbes (United States Patent 4,126,516)
Identification of non-fermentative gram-negative bacteria (United States Patent 4,048,016)
Certain quaternary ammonium salts used to control gram-negative bacteria (United States Patent 4,015,013)
Antibacterial agents for Gram-negative bacteria (United States Patent 4,012,359)
Polypeptides obtained from gram negative microbes (United States Patent 7,138,124)
Compositions and methods for eliciting an immune response to gram-negative bacterial infections (United States Patent 7,135,175)
Production or aromatic carotenoids in gram negative bacteria (United States Patent 7,132,257)
Compositions and methods for eliciting an immune response to gram-negative bacterial infections (United States Patent 7,132,101)
Vaccine against Gram-negative bacterial infections (United States Patent 7,025,963)
Vaccine against Gram-negative bacterial infections (United States Patent 7,018,636)
Mutants of gram negative mucosal bacteria and application thereof in vaccines (United States Patent 7,011,836)
Non-toxic mutants of pathogenic gram-negative bacteria (United States Patent 7,005,129)
Method for detecting a gram-negative bacterial autoinducer molecule (United States Patent 6,979,696)
Method for detecting a gram-negative bacterial autoinducer molecule (United States Patent 6,958,219)
Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases (United States Patent 6,951,652)
Preparation and uses of los-depleted outer membrane proteins of gram-negative cocci (United States Patent 6,921,537)
Non-toxic mutants of pathogenic gram-negative bacteria (United States Patent 6,887,483)
Conjugate vaccine against gram-negative bacterial infections (United States Patent 6,872,398)
Antibodies raised against immunogenic conjugates of gram-negative bacterial autoinducer molecules (United States Patent 6,713,059)
Method for screening for inhibitors and activators of type III secretion machinery in gram-negative bacteria (United States Patent 6,696,249)
Invaplex from gram negative bacteria, method of purification and methods of use (United States Patent 6,680,374)
Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria (United States Patent 6,645,503)
Live vaccines against gram-negative pathogens, expressing heterologous O-antigens (United States Patent 6,613,321)
Bacterial gene and method of treating a gram negative bacterial infection (United States Patent 6,570,006)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.