PATENTS RELATED TO HEMOGLOBIN

Although Dr. Demchick also represents patent seekers with non-biological inventions, his doctorate is in biology. Biology has been the primary focus of his research and teaching. He especially loves dealing with patent searches and applications for involving biology.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.

If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.

The following sampling is to give you some sense of the types of hemoglobin related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.

It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof (United States Patent 7,144,989)

Method of forming a polymerized hemoglobin solution from stabilized hemoglobin (United States Patent 7,135,554)

Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing (United States Patent 7,135,553)

Method and apparatus for measuring cell-by-cell hemoglobin (United States Patent 7,095,492)

Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging (United States Patent 7,049,406)

Preserving a hemoglobin blood substitute with a transparent overwrap (United States Patent 7,041,800)

Preserving a hemoglobin blood substitute with a transparent overwrap (United States Patent 7,041,799)

Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution (United States Patent 7,038,016)

Bacterial hemoglobin receptor genes (United States Patent 7,026,157)

Reagent for determination of leucocytes and measurement of haemoglobin in a sample of blood (United States Patent 7,026,110)

Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy alkylene glycols (United States Patent 7,019,117)

Synthetic oxygen transport made from cross-linked modified human or porcine haemoglobin with improved properties, method for a preparation thereof from purified material and use thereof (United States Patent 7,005,414)

Method for the determination of glycated hemoglobin (United States Patent 7,005,273)

Assay method of a complex of lipoprotein with hemoglobin or hemoglobin analog (United States Patent 6,994,955)

Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier (United States Patent 6,986,984)

Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin (United States Patent 6,974,795)

Hemoglobin-antioxidant conjugates (United States Patent 6,974,794)

Mammalian haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof (United States Patent 6,956,025)

Determination of pH including hemoglobin correction (United States Patent 6,944,487)

Nonsymbiotic plant hemoglobins to maintain cell energy status (United States Patent 6,936,749)

Method of inducing fetal hemoglobin synthesis (United States Patent 6,936,254)

Photoreduction method for hemoglobin-vesicle (United States Patent 6,916,303)

No-modified hemoglobins and uses therefore (United States Patent 6,911,427)

Substituted chiral allosteric hemoglobin modifiers (United States Patent 6,894,185)

Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin (United States Patent 6,894,150)

Method of using cyanide-free lyse solution to emulate a cyanide-containing lyse solution in the measurement of hemoglobin (United States Patent 6,890,756)

Modified hemoglobins, including nitrosylhemoglobins, and uses thereof (United States Patent 6,884,773)

NUCLEIC ACID AND AMINO ACID SEQUENCES OF HEMOGLOBIN-RESPONSE GENES IN CANDIDA ALBICANS AND THE USE OF REAGENTS DERIVED FROM THESE SEQUENCES IN THE DIAGNOSIS OF DISSEMINATED CANDIDA ALBICANS INFECTION (United States Patent 6,875,855)

Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation (United States Patent 6,858,583)

Methods for oxygen transport comprising a high oxygen affinity modified hemoglobin (United States Patent 6,844,317)

Methods for determination of the ratio of glycated haemoglobin to nonglycated haemoglobin (United States Patent 6,818,416)

Low oxygen affinity mutant hemoglobins (United States Patent 6,812,328)

Hemoglobin mutants that reduce heme loss (United States Patent 6,812,207)

Low oxygen affinity mutant hemoglobins (United States Patent 6,808,898)

Low oxygen affinity mutant hemoglobins (United States Patent 6,803,212)

Method for measuring hemoglobin concentration (HGB) in the blood in a circuit of a dialysis machine, measuring device and circuit for the application of the method (United States Patent 6,794,194)

Method of quantifying hemoglobin and method of measuring glycation ratio of hemoglobin (United States Patent 6,790,665)

Polymeric hemoglobin mutants (United States Patent 6,780,892)

Method for production of stroma-free hemoglobin (United States Patent 6,773,613)

Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit (United States Patent 6,751,490)

Methods for the synthesis of a modified hemoglobin solution (United States Patent 6,747,132)

Methods and reagents for cyanide-free determination of hemoglobin and leukocytes in whole blood (United States Patent 6,740,527)

Method for determining alkaline phosphatase and eliminating haemoglobin disturbances (United States Patent 6,720,163)

Method and apparatus for noninvasively monitoring hemoglobin concentration and oxygen saturation (United States Patent 6,714,805)

Method and apparatus for determination of pH pCO2, hemoglobin, and hemoglobin oxygen saturation (United States Patent 6,694,157)

System and method for measuring blood urea nitrogen, blood osmolarity, plasma free hemoglobin and tissue water content (United States Patent 6,687,519)

Method for measurement of glycated hemoglobin by a rapid strip test procedure (United States Patent 6,677,158)

Reduced side-effect hemoglobin compositions (United States Patent 6,670,323)

Nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex (United States Patent 6,667,292)

Method and device for the noninvasive determination of hemoglobin and hematocrit (United States Patent 6,662,031)

Hemoglobin sensor (United States Patent 6,632,349)

No-modified hemoglobins and uses therefor (United States Patent 6,627,738)

Automated method for detecting, quantifying and monitoring exogenous hemoglobin in whole blood, plasma and serum (United States Patent 6,623,972)

Apparatus for determining concentrations of hemoglobins (United States Patent 6,622,095)

Method for stimulating the production of fetal hemoglobin producing erythroid cells (United States Patent 6,617,158)

Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human mammals (United States Patent 6,613,957)

Preserving a hemoglobin blood substitute with a transparent overwrap (United States Patent 6,610,832)

Superoxygenating blood substitutes based on hemoglobin and dihydropyidine compositions (United States Patent 6,599,878)

Chemically modified hemoglobin for burn shock resuscitation (United States Patent 6,566,326)

Method for quantitative determination of glycated hemoglobin (United States Patent 6,562,581)

Complex of lipoprotein with hemoglobin or hemoglobin analog (United States Patent 6,524,862)

Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier (United States Patent 6,518,010)

Ultra pure hemoglobin solutions and blood-substitutes (United States Patent 6,506,725)

Hemoglobin-polysaccharide conjugates (United States Patent 6,500,930)

Method of separating hemoglobin A2 (United States Patent 6,488,857)

Substituted chiral allosteric hemoglobin modifiers (United States Patent 6,486,342)

Low oxygen affinity mutant hemoglobins (United States Patent 6,486,123)

Hemoglobin-haptoglobin complexes (United States Patent 6,479,637)

Total hemoglobin concentration measurement (United States Patent 6,473,632)

Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis (United States Patent 6,458,762)

Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging (United States Patent 6,455,676)

Pharmaceutical combination preparations containing erythropoietin and modified haemoglobins (United States Patent 6,440,932)

Method for determination of hemoglobins (United States Patent 6,428,704)

Use of hemoglobin derivatives for determining plasma and/or blood volume (United States Patent 6,416,736)

Apparatus for determining concentrations of hemoglobins (United States Patent 6,415,236)

Methods and test devices for determination of glycated haemoglobin (United States Patent 6,399,293)

Hemoglobin genes and their use (United States Patent 6,372,961)

Efficient culture of stem cells for the production of hemoglobin (United States Patent 6,361,998)

Method for producing human hemoglobin proteins using plant cells (United States Patent 6,344,600)

Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute (United States Patent 6,323,175)

Determination of % glycated hemoglobin (United States Patent 6,316,265)

Preserving a hemoglobin blood substitute with a transparent overwrap (United States Patent 6,288,027)

Hemoglobin receptors from neisseriae (United States Patent 6,277,382)

Method for preserving a hemoglobin blood substitute (United States Patent 6,271,351)

System and method for measuring blood urea nitrogen, blood osmolarity, plasma free hemoglobin and tissue water content (United States Patent 6,246,894)

Stabilized compositions containing hemoglobin (United States Patent 6,242,417)

Method for measuring absolute saturation of time-varying and other hemoglobin compartments (United States Patent 6,216,021)

Method for the analysis of medical samples containing haemoglobin (United States Patent 6,207,459)

Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations (United States Patent 6,204,009)

Methods for producing nitrosated hemoglobins and therapeutic uses therefor (United States Patent 6,197,745)

Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject (United States Patent 6,187,744)

Production and use of multimeric hemoglobins (United States Patent 6,184,356)

Covalently modified hemoglobin having low temperature-dependent oxygen-binding function (United States Patent 6,180,598)

Measurement of glycated hemoglobin (United States Patent 6,174,734)

Control or calibration standard for use with instruments for optical measurement of hemoglobin concentration in blood samples (United States Patent 6,174,728)

Expression of recombinant hemoglobin and hemoglobin variants in yeast (United States Patent 6,172,039)

Methods of controlling beta dimer formation in hemoglobin (United States Patent 6,171,826)

Determination of % glycated hemoglobin (United States Patent 6,162,645)

Method for control of functionality during cross-linking of hemoglobins (United States Patent 6,160,098)

Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof (United States Patent 7,144,989)

Method of forming a polymerized hemoglobin solution from stabilized hemoglobin (United States Patent 7,135,554)

Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing (United States Patent 7,135,553)

Method and apparatus for measuring cell-by-cell hemoglobin (United States Patent 7,095,492)

Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging (United States Patent 7,049,406)

Preserving a hemoglobin blood substitute with a transparent overwrap (United States Patent 7,041,800)

Preserving a hemoglobin blood substitute with a transparent overwrap (United States Patent 7,041,799)

Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution (United States Patent 7,038,016)

Bacterial hemoglobin receptor genes (United States Patent 7,026,157)

Reagent for determination of leucocytes and measurement of haemoglobin in a sample of blood (United States Patent 7,026,110)

Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy alkylene glycols (United States Patent 7,019,117)

Synthetic oxygen transport made from cross-linked modified human or porcine haemoglobin with improved properties, method for a preparation thereof from purified material and use thereof (United States Patent 7,005,414)

Method for the determination of glycated hemoglobin (United States Patent 7,005,273)

Assay method of a complex of lipoprotein with hemoglobin or hemoglobin analog (United States Patent 6,994,955)

Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier (United States Patent 6,986,984)

Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin (United States Patent 6,974,795)

Hemoglobin-antioxidant conjugates (United States Patent 6,974,794)

Mammalian haemoglobin compatible with blood plasma, cross-linked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, production and use thereof (United States Patent 6,956,025)

Determination of pH including hemoglobin correction (United States Patent 6,944,487)

Nonsymbiotic plant hemoglobins to maintain cell energy status (United States Patent 6,936,749)

Method of inducing fetal hemoglobin synthesis (United States Patent 6,936,254)

Photoreduction method for hemoglobin-vesicle (United States Patent 6,916,303)

No-modified hemoglobins and uses therefore (United States Patent 6,911,427)

Substituted chiral allosteric hemoglobin modifiers (United States Patent 6,894,185)

Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin (United States Patent 6,894,150)

Method of using cyanide-free lyse solution to emulate a cyanide-containing lyse solution in the measurement of hemoglobin (United States Patent 6,890,756)

Modified hemoglobins, including nitrosylhemoglobins, and uses thereof (United States Patent 6,884,773)

NUCLEIC ACID AND AMINO ACID SEQUENCES OF HEMOGLOBIN-RESPONSE GENES IN CANDIDA ALBICANS AND THE USE OF REAGENTS DERIVED FROM THESE SEQUENCES IN THE DIAGNOSIS OF DISSEMINATED CANDIDA ALBICANS INFECTION (United States Patent 6,875,855)

Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation (United States Patent 6,858,583)

Methods for oxygen transport comprising a high oxygen affinity modified hemoglobin (United States Patent 6,844,317)

Methods for determination of the ratio of glycated haemoglobin to nonglycated haemoglobin (United States Patent 6,818,416)

Low oxygen affinity mutant hemoglobins (United States Patent 6,812,328)

Hemoglobin mutants that reduce heme loss (United States Patent 6,812,207)

Low oxygen affinity mutant hemoglobins (United States Patent 6,808,898)

Low oxygen affinity mutant hemoglobins (United States Patent 6,803,212)

Method for measuring hemoglobin concentration (HGB) in the blood in a circuit of a dialysis machine, measuring device and circuit for the application of the method (United States Patent 6,794,194)

Method of quantifying hemoglobin and method of measuring glycation ratio of hemoglobin (United States Patent 6,790,665)

Polymeric hemoglobin mutants (United States Patent 6,780,892)

Method for production of stroma-free hemoglobin (United States Patent 6,773,613)

Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit (United States Patent 6,751,490)

Methods for the synthesis of a modified hemoglobin solution (United States Patent 6,747,132)

Methods and reagents for cyanide-free determination of hemoglobin and leukocytes in whole blood (United States Patent 6,740,527)

Method for determining alkaline phosphatase and eliminating haemoglobin disturbances (United States Patent 6,720,163)

Method and apparatus for noninvasively monitoring hemoglobin concentration and oxygen saturation (United States Patent 6,714,805)

Method and apparatus for determination of pH pCO2, hemoglobin, and hemoglobin oxygen saturation (United States Patent 6,694,157)

System and method for measuring blood urea nitrogen, blood osmolarity, plasma free hemoglobin and tissue water content (United States Patent 6,687,519)

Method for measurement of glycated hemoglobin by a rapid strip test procedure (United States Patent 6,677,158)

Reduced side-effect hemoglobin compositions (United States Patent 6,670,323)

Nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex (United States Patent 6,667,292)

Method and device for the noninvasive determination of hemoglobin and hematocrit (United States Patent 6,662,031)

Hemoglobin sensor (United States Patent 6,632,349)

No-modified hemoglobins and uses therefor (United States Patent 6,627,738)

Automated method for detecting, quantifying and monitoring exogenous hemoglobin in whole blood, plasma and serum (United States Patent 6,623,972)

Apparatus for determining concentrations of hemoglobins (United States Patent 6,622,095)

Method for stimulating the production of fetal hemoglobin producing erythroid cells (United States Patent 6,617,158)

Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human mammals (United States Patent 6,613,957)

Preserving a hemoglobin blood substitute with a transparent overwrap (United States Patent 6,610,832)

Superoxygenating blood substitutes based on hemoglobin and dihydropyidine compositions (United States Patent 6,599,878)

Chemically modified hemoglobin for burn shock resuscitation (United States Patent 6,566,326)

Method for quantitative determination of glycated hemoglobin (United States Patent 6,562,581)

Complex of lipoprotein with hemoglobin or hemoglobin analog (United States Patent 6,524,862)

Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier (United States Patent 6,518,010)

Ultra pure hemoglobin solutions and blood-substitutes (United States Patent 6,506,725)

Hemoglobin-polysaccharide conjugates (United States Patent 6,500,930)

Method of separating hemoglobin A2 (United States Patent 6,488,857)

Substituted chiral allosteric hemoglobin modifiers (United States Patent 6,486,342)

Low oxygen affinity mutant hemoglobins (United States Patent 6,486,123)

Hemoglobin-haptoglobin complexes (United States Patent 6,479,637)

Total hemoglobin concentration measurement (United States Patent 6,473,632)

Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis (United States Patent 6,458,762)

Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging (United States Patent 6,455,676)

Pharmaceutical combination preparations containing erythropoietin and modified haemoglobins (United States Patent 6,440,932)

Method for determination of hemoglobins (United States Patent 6,428,704)

Use of hemoglobin derivatives for determining plasma and/or blood volume (United States Patent 6,416,736)

Apparatus for determining concentrations of hemoglobins (United States Patent 6,415,236)

Methods and test devices for determination of glycated haemoglobin (United States Patent 6,399,293)

Hemoglobin genes and their use (United States Patent 6,372,961)

Efficient culture of stem cells for the production of hemoglobin (United States Patent 6,361,998)

Method for producing human hemoglobin proteins using plant cells (United States Patent 6,344,600)

Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute (United States Patent 6,323,175)

Determination of % glycated hemoglobin (United States Patent 6,316,265)

Preserving a hemoglobin blood substitute with a transparent overwrap (United States Patent 6,288,027)

Hemoglobin receptors from neisseriae (United States Patent 6,277,382)

Method for preserving a hemoglobin blood substitute (United States Patent 6,271,351)

System and method for measuring blood urea nitrogen, blood osmolarity, plasma free hemoglobin and tissue water content (United States Patent 6,246,894)

Stabilized compositions containing hemoglobin (United States Patent 6,242,417)

Method for measuring absolute saturation of time-varying and other hemoglobin compartments (United States Patent 6,216,021)

Method for the analysis of medical samples containing haemoglobin (United States Patent 6,207,459)

Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations (United States Patent 6,204,009)

Methods for producing nitrosated hemoglobins and therapeutic uses therefor (United States Patent 6,197,745)

Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject (United States Patent 6,187,744)

Production and use of multimeric hemoglobins (United States Patent 6,184,356)

Covalently modified hemoglobin having low temperature-dependent oxygen-binding function (United States Patent 6,180,598)

Measurement of glycated hemoglobin (United States Patent 6,174,734)

Control or calibration standard for use with instruments for optical measurement of hemoglobin concentration in blood samples (United States Patent 6,174,728)

Expression of recombinant hemoglobin and hemoglobin variants in yeast (United States Patent 6,172,039)

Methods of controlling beta dimer formation in hemoglobin (United States Patent 6,171,826)

Determination of % glycated hemoglobin (United States Patent 6,162,645)

Method for control of functionality during cross-linking of hemoglobins (United States Patent 6,160,098)

Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof (United States Patent 7,144,989)

Method of forming a polymerized hemoglobin solution from stabilized hemoglobin (United States Patent 7,135,554)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.