PATENTS RELATED TO LYOPHILIZATION

Although it is not necessary for a patent agent to have personal experience with the specific subject matter, it has its advantages. Dr. Demchick's experience includes laboratory experience involving lyophilization.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.

If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.

The following sampling is to give you some sense of the types of lyophilization related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.

It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Process for manufacturing bulk solutions and a lyophilized pure .alpha.-aztreonam lysinate (United States Patent 7,138,419)

Stabilized pharmaceutical composition in lyophilized form (United States Patent 7,112,565)

Lyophilized powder of lentinan and the process of preparation thereof (United States Patent 7,091,336)

Lyophilization method and apparatus for producing particles (United States Patent 7,073,349)

Methods for lyophilizing competent cells (United States Patent 6,960,464)

Lyophilization method and apparatus for producing particles (United States Patent 6,931,888)

Method and apparatus for the storage and transfer of a lyophilisate (United States Patent 6,918,418)

Method for lyophilizing an active agent (United States Patent 6,907,679)

Pharmaceutical preparation of recombinant factor VIII lyophilized without albumin as a stabilizer (United States Patent 6,887,852)

Preparation and use of oligopeptide lyophilisate for gonad protection (United States Patent 6,867,191)

Oligopeptide lyophilisate, their preparation and use (United States Patent 6,863,891)

Preparation of submicron sized nanoparticles via dispersion lyophilization (United States Patent 6,835,396)

Oligopeptide lyophilisate, their preparation and use (United States Patent 6,828,415)

Stabilized pharmaceutical composition in lyophilized form (United States Patent 6,774,104)

Lyophilisates having improved reconstitutability (United States Patent 6,770,678)

Lyophilized tubulins (United States Patent 6,750,330)

Process and delivery container for lyophilizing active agent (United States Patent 6,722,054)

Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments (United States Patent 6,686,460)

Sterile lyophilized ifosfamide and associated methods (United States Patent 6,613,927)

System for use in lyophilization comprising delivery containers and a cover plate (United States Patent 6,610,252)

Lyophilizate of lipid complex of water insoluble porphyrins (United States Patent 6,608,050)

Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents (United States Patent 6,605,438)

Process for viral inactivation of lyophilized blood proteins (United States Patent 6,566,504)

Cover plate for use in lyophilization (United States Patent 6,566,144)

Lyophilizate of lipid complex of water insoluble camptothecins (United States Patent 6,548,071)

Container for lyophilizing biological products (United States Patent 6,517,526)

Excipient for the lyophilization of aqueous suspensions of microparticles (United States Patent 6,482,518)

Apparatus and method for delivering a lyophilized active with a needle-less injector (United States Patent 6,474,369)

Peptide/lipid complex formation by co-lyophilization (United States Patent 6,455,088)

Syringe systems for lyophilized drugs and methods for making the same (United States Patent 6,440,101)

Lyophilized compositions containing shingoglycolipid and process for preparing them (United States Patent 6,417,167)

Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments (United States Patent 6,410,321)

Pharmaceutical preparation comprising lyophilized liposomes encapsulating an active principle which is highly insoluble in water, and the process for preparing the said preparation (United States Patent 6,319,517)

Stabilizers for lyophilized vaccines (United States Patent 6,290,967)

Peptide/lipid complex formation by co-lyophilization (United States Patent 6,287,590)

Method and device for production of lyophilized hydrochloride-1.beta., 10.beta.-epoxy-13-dimethylamino-guaia-3(4)-en-6,12-olide (United States Patent 6,242,617)

Dual vial connecting system for lyophilized products (United States Patent 6,237,649)

Microwave lyophilizer having corona discharge control (United States Patent 6,225,611)

Method of making lyophilized microbubble compositions useful as contrast agents (United States Patent 6,217,850)

Lyophilization apparatus and methods (United States Patent 6,199,297)

Sustained-released material prepared by dispersing a lyophilized polypeptide in an oil phase (United States Patent 6,190,702)

Lyophilized monolithic bone implant and method for treating bone (United States Patent 6,162,258)

Lyophilized reagent for polymerase chain reaction (United States Patent 6,153,412)

Methods for lyophilizing and using ericoid mycorrhizal fungi (United States Patent 6,146,880)

Lyophilized platelet composition containing chloroquine, hydroxychloroquine, camoquin, quinacrine or procaine (United States Patent 6,127,111)

Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same (United States Patent 6,111,098)

Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments (United States Patent 6,071,745)

Methods for the lyophilization of platelets, platelet membranes or erythrocytes (United States Patent 6,060,233)

Stabilizers for lyophilized mumps vaccines (United States Patent 6,051,238)

Methods for the lyophilization of living biological materials (United States Patent 6,040,132)

Lyophilized imaging agent formulation comprising a chemotactic peptide (United States Patent 6,024,938)

Lyophilized ionizing radiation sterilized microorganisms as an additive for nutrient media for growing bacteria (United States Patent 6,010,896)

Method for stabilizing compound DX-52-1 and lyophilized composition thereof (United States Patent 5,977,109)

Method for lyophilizing ifosfamide (United States Patent 5,972,912)

Lyophilized pulmonary surfactant peptide compositions (United States Patent 5,952,303)

Lyophilizer system (United States Patent 5,948,144)

Stable lyophilized pharmaceutical preparations of G-CSF (United States Patent 5,919,443)

Dendrimer-based networks containing lyophilic organosilicon and hydrophilic polyamidoamine nanoscopic domains (United States Patent 5,902,863)

Submicron liposome suspensions obtained from preliposome lyophilizates (United States Patent 5,902,604)

Composition for feed use comprising lyophilized live lactic bacteria (United States Patent 5,895,648)

Method of producing storage stable M-CSF lyophilizates (United States Patent 5,888,495)

Lyophilized emulsion containing an active substance (United States Patent 5,882,684)

Lyophilized reagent for polymerase chain reaction (United States Patent 5,861,251)

Method of lyophilization of mammalian sperm cells (United States Patent 5,849,473)

Method for lyophilizing food using xanthomonas campestris ferm BP-4191 as an ice nucleus-forming substance (United States Patent 5,843,506)

Lyophilization closure assembly for a medicament container for use during a lyophilization process (United States Patent 5,819,964)

Stable liquid composition containing urate oxidase and lyophilized composition for its preparation (United States Patent 5,811,096)

Syringe barrel for lyophilization, reconstitution and administration (United States Patent 5,779,668)

Method of preparing gas-filled microspheres using a lyophilized lipids (United States Patent 5,776,429)

Lyophilized composition containing S(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione) (United States Patent 5,760,039)

Method of detecting circulating antibody types using dried or lyophilized cells (United States Patent 5,759,774)

Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation (United States Patent 5,756,552)

Cationic lipid acid salt of 3beta[N- (N', N'-dimethylaminoethane) - carbamoyl]cholestrol and halogenated solvent-free preliposomal lyophilate thereof (United States Patent 5,753,262)

Syringe and method for lyophilizing and reconstituting injectable medication (United States Patent 5,752,940)

Method and composition for lyophilizing red blood cells (United States Patent 5,750,330)

Ifosfamide lyophilizate preparations (United States Patent 5,750,131)

Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing (United States Patent 5,736,313)

Partially lyophilized fructose-1,6-diphosphate (FDP) for injection into humans (United States Patent 5,731,291)

Lyophilized bioluminescent bacterial reagent for the detection of toxicants (United States Patent 5,731,163)

Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba (United States Patent 5,730,987)

PGE-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction (United States Patent 5,718,917)

Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use (United States Patent 5,716,615)

Lyophilized thioxanthenone antitumor agents (United States Patent 5,665,760)

In-situ lyophilization of vaginal suppository in unit dose applicator and resultant product (United States Patent 5,656,283)

Lyophilization of cells (United States Patent 5,648,206)

Method of preparing lyophilized and frozen cell standards (United States Patent 5,641,637)

Lyophilized fatty emulsions and a process for the production thereof (United States Patent 5,635,491)

Lyophilized health food products and methods of making same (United States Patent 5,616,355)

Lyophilized emulsion containing an active substance (United States Patent 5,612,058)

Stable lyophilized thiotepa composition (United States Patent 5,561,121)

Lyophilized polyethylene oxide modified protein and polypeptide complexes with cyclodextrin (United States Patent 5,529,915)

Syringe assembly and method for lyophilizing and reconstituting injectable medication (United States Patent 5,489,266)

Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same (United States Patent 5,454,786)

Reacting an enzyme in a non-aqueous solvent by adding a lyophilizate of enzyme and salt to the solvent (United States Patent 5,449,613)

Process for the regulation of lyophilization (United States Patent 5,428,905)

Method of reconstituting lyophilized cells (United States Patent 5,425,951)

Method for lyophilization of cyclophosphamide and product (United States Patent 5,418,223)

Lyophilized cyclophosphamide (United States Patent 5,413,995)

Process for manufacturing bulk solutions and a lyophilized pure .alpha.-aztreonam lysinate (United States Patent 7,138,419)

Stabilized pharmaceutical composition in lyophilized form (United States Patent 7,112,565)

Lyophilized powder of lentinan and the process of preparation thereof (United States Patent 7,091,336)

Lyophilization method and apparatus for producing particles (United States Patent 7,073,349)

Methods for lyophilizing competent cells (United States Patent 6,960,464)

Lyophilization method and apparatus for producing particles (United States Patent 6,931,888)

Method and apparatus for the storage and transfer of a lyophilisate (United States Patent 6,918,418)

Method for lyophilizing an active agent (United States Patent 6,907,679)

Pharmaceutical preparation of recombinant factor VIII lyophilized without albumin as a stabilizer (United States Patent 6,887,852)

Preparation and use of oligopeptide lyophilisate for gonad protection (United States Patent 6,867,191)

Oligopeptide lyophilisate, their preparation and use (United States Patent 6,863,891)

Preparation of submicron sized nanoparticles via dispersion lyophilization (United States Patent 6,835,396)

Oligopeptide lyophilisate, their preparation and use (United States Patent 6,828,415)

Stabilized pharmaceutical composition in lyophilized form (United States Patent 6,774,104)

Lyophilisates having improved reconstitutability (United States Patent 6,770,678)

Lyophilized tubulins (United States Patent 6,750,330)

Process and delivery container for lyophilizing active agent (United States Patent 6,722,054)

Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments (United States Patent 6,686,460)

Sterile lyophilized ifosfamide and associated methods (United States Patent 6,613,927)

System for use in lyophilization comprising delivery containers and a cover plate (United States Patent 6,610,252)

Lyophilizate of lipid complex of water insoluble porphyrins (United States Patent 6,608,050)

Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents (United States Patent 6,605,438)

Process for viral inactivation of lyophilized blood proteins (United States Patent 6,566,504)

Cover plate for use in lyophilization (United States Patent 6,566,144)

Lyophilizate of lipid complex of water insoluble camptothecins (United States Patent 6,548,071)

Container for lyophilizing biological products (United States Patent 6,517,526)

Excipient for the lyophilization of aqueous suspensions of microparticles (United States Patent 6,482,518)

Apparatus and method for delivering a lyophilized active with a needle-less injector (United States Patent 6,474,369)

Peptide/lipid complex formation by co-lyophilization (United States Patent 6,455,088)

Syringe systems for lyophilized drugs and methods for making the same (United States Patent 6,440,101)

Lyophilized compositions containing shingoglycolipid and process for preparing them (United States Patent 6,417,167)

Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments (United States Patent 6,410,321)

Pharmaceutical preparation comprising lyophilized liposomes encapsulating an active principle which is highly insoluble in water, and the process for preparing the said preparation (United States Patent 6,319,517)

Stabilizers for lyophilized vaccines (United States Patent 6,290,967)

Peptide/lipid complex formation by co-lyophilization (United States Patent 6,287,590)

Method and device for production of lyophilized hydrochloride-1.beta., 10.beta.-epoxy-13-dimethylamino-guaia-3(4)-en-6,12-olide (United States Patent 6,242,617)

Dual vial connecting system for lyophilized products (United States Patent 6,237,649)

Microwave lyophilizer having corona discharge control (United States Patent 6,225,611)

Method of making lyophilized microbubble compositions useful as contrast agents (United States Patent 6,217,850)

Lyophilization apparatus and methods (United States Patent 6,199,297)

Sustained-released material prepared by dispersing a lyophilized polypeptide in an oil phase (United States Patent 6,190,702)

Lyophilized monolithic bone implant and method for treating bone (United States Patent 6,162,258)

Lyophilized reagent for polymerase chain reaction (United States Patent 6,153,412)

Methods for lyophilizing and using ericoid mycorrhizal fungi (United States Patent 6,146,880)

Lyophilized platelet composition containing chloroquine, hydroxychloroquine, camoquin, quinacrine or procaine (United States Patent 6,127,111)

Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same (United States Patent 6,111,098)

Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments (United States Patent 6,071,745)

Methods for the lyophilization of platelets, platelet membranes or erythrocytes (United States Patent 6,060,233)

Stabilizers for lyophilized mumps vaccines (United States Patent 6,051,238)

Methods for the lyophilization of living biological materials (United States Patent 6,040,132)

Lyophilized imaging agent formulation comprising a chemotactic peptide (United States Patent 6,024,938)

Lyophilized ionizing radiation sterilized microorganisms as an additive for nutrient media for growing bacteria (United States Patent 6,010,896)

Method for stabilizing compound DX-52-1 and lyophilized composition thereof (United States Patent 5,977,109)

Method for lyophilizing ifosfamide (United States Patent 5,972,912)

Lyophilized pulmonary surfactant peptide compositions (United States Patent 5,952,303)

Lyophilizer system (United States Patent 5,948,144)

Stable lyophilized pharmaceutical preparations of G-CSF (United States Patent 5,919,443)

Dendrimer-based networks containing lyophilic organosilicon and hydrophilic polyamidoamine nanoscopic domains (United States Patent 5,902,863)

Submicron liposome suspensions obtained from preliposome lyophilizates (United States Patent 5,902,604)

Composition for feed use comprising lyophilized live lactic bacteria (United States Patent 5,895,648)

Method of producing storage stable M-CSF lyophilizates (United States Patent 5,888,495)

Lyophilized emulsion containing an active substance (United States Patent 5,882,684)

Lyophilized reagent for polymerase chain reaction (United States Patent 5,861,251)

Method of lyophilization of mammalian sperm cells (United States Patent 5,849,473)

Method for lyophilizing food using xanthomonas campestris ferm BP-4191 as an ice nucleus-forming substance (United States Patent 5,843,506)

Lyophilization closure assembly for a medicament container for use during a lyophilization process (United States Patent 5,819,964)

Stable liquid composition containing urate oxidase and lyophilized composition for its preparation (United States Patent 5,811,096)

Syringe barrel for lyophilization, reconstitution and administration (United States Patent 5,779,668)

Method of preparing gas-filled microspheres using a lyophilized lipids (United States Patent 5,776,429)

Lyophilized composition containing S(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione) (United States Patent 5,760,039)

Method of detecting circulating antibody types using dried or lyophilized cells (United States Patent 5,759,774)

Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation (United States Patent 5,756,552)

Cationic lipid acid salt of 3beta[N- (N', N'-dimethylaminoethane) - carbamoyl]cholestrol and halogenated solvent-free preliposomal lyophilate thereof (United States Patent 5,753,262)

Syringe and method for lyophilizing and reconstituting injectable medication (United States Patent 5,752,940)

Method and composition for lyophilizing red blood cells (United States Patent 5,750,330)

Ifosfamide lyophilizate preparations (United States Patent 5,750,131)

Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing (United States Patent 5,736,313)

Partially lyophilized fructose-1,6-diphosphate (FDP) for injection into humans (United States Patent 5,731,291)

Lyophilized bioluminescent bacterial reagent for the detection of toxicants (United States Patent 5,731,163)

Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba (United States Patent 5,730,987)

PGE-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction (United States Patent 5,718,917)

Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use (United States Patent 5,716,615)

Lyophilized thioxanthenone antitumor agents (United States Patent 5,665,760)

In-situ lyophilization of vaginal suppository in unit dose applicator and resultant product (United States Patent 5,656,283)

Lyophilization of cells (United States Patent 5,648,206)

Method of preparing lyophilized and frozen cell standards (United States Patent 5,641,637)

Lyophilized fatty emulsions and a process for the production thereof (United States Patent 5,635,491)

Lyophilized health food products and methods of making same (United States Patent 5,616,355)

Lyophilized emulsion containing an active substance (United States Patent 5,612,058)

Stable lyophilized thiotepa composition (United States Patent 5,561,121)

Lyophilized polyethylene oxide modified protein and polypeptide complexes with cyclodextrin (United States Patent 5,529,915)

Syringe assembly and method for lyophilizing and reconstituting injectable medication (United States Patent 5,489,266)

Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same (United States Patent 5,454,786)

Reacting an enzyme in a non-aqueous solvent by adding a lyophilizate of enzyme and salt to the solvent (United States Patent 5,449,613)

Process for the regulation of lyophilization (United States Patent 5,428,905)

Method of reconstituting lyophilized cells (United States Patent 5,425,951)

Method for lyophilization of cyclophosphamide and product (United States Patent 5,418,223)

Lyophilized cyclophosphamide (United States Patent 5,413,995)

Process for manufacturing bulk solutions and a lyophilized pure .alpha.-aztreonam lysinate (United States Patent 7,138,419)

Stabilized pharmaceutical composition in lyophilized form (United States Patent 7,112,565)

Lyophilized powder of lentinan and the process of preparation thereof (United States Patent 7,091,336)

Lyophilization method and apparatus for producing particles (United States Patent 7,073,349)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.