PATENTS RELATED TO MUTAGENESIS

Professor Demchick's Patent Services

Paul H. Demchick, United States Registered Patent Agent
(United States Patent and Trademark Office Registration 52,808)

PATENTS RELATED TO MUTAGENESIS

Although Dr. Demchick also represents patent seekers with non-biological inventions, his doctorate is in biology. Biology has been the primary focus of his research and teaching. He especially loves dealing with patent searches and applications for involving biology.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.
If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.
The following sampling is to give you some sense of the types of mutagenesis related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.
It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Circular site-directed mutagenesis (United States Patent 7,132,265)
Chemically modified oligonucleotide for site-directed mutagenesis (United States Patent 7,078,389)
Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating (United States Patent 7,033,781)
System and method for transgenic and targeted mutagenesis screening (United States Patent 6,977,178)
Mutagenesis method (United States Patent 6,949,383)
Method of constructing vectors for homologous recombination directed mutagenesis (United States Patent 6,924,146)
Method for multiple site-directed mutagenesis (United States Patent 6,878,531)
Site-directed mutagenesis of Escherichia coli phytase (United States Patent 6,841,370)
Method for the mutagenesis of nucleotide sequences in plants algae or fungi (United States Patent 6,824,983)
Vectors for gene mutagenesis and gene discovery (United States Patent 6,808,921)
Compositions and methods for random nucleic acid mutagenesis (United States Patent 6,803,216)
Vectors for gene mutagenesis and gene discovery (United States Patent 6,776,988)
Saturation mutageneis in directed evolution (United States Patent 6,764,835)
Method for large scale mutagenesis in tomato plants (United States Patent 6,759,569)
Circular site-directed mutagenesis (United States Patent 6,713,285)
Method for mutagenesis (United States Patent 6,673,610)
Composition and method for detecting mutagens (United States Patent 6,667,153)
Walk-through mutagenesis (United States Patent 6,649,340)
Polynucleotides for mutagenesis in fungus comprising a functional gene in magnaporthe and an impala transposon (United States Patent 6,617,163)
Recombinant nucleic acid sequences and methods for determining both genotoxicity and mutagenicity of a sample and the kinetics of the genotoxicity (United States Patent 6,602,666)
Saturation mutagenesis in directed evolution (United States Patent 6,562,594)
Recombinant nucleic acid sequences and methods for determining both genotoxicity and mutagenicity of a sample and the kinetics of the genotoxicity (United States Patent 6,521,751)
Method for effecting site-directed mutagenesis (United States Patent 6,448,048)
Vectors for gene mutagenesis and gene discovery (United States Patent 6,436,707)
Circular site-directed mutagenesis (United States Patent 6,391,548)
Methods of evolving a polynucleotides by mutagenesis and recombination (United States Patent 6,365,408)
Methods of replicating a DNA molecule for repair of DNA lesion damage or for mutagenesis (United States Patent 6,333,178)
Methods of targeted mutagenesis using triple-helix forming oligonucleotides (United States Patent 6,303,376)
Mutagenized IL 13-based chimeric molecules (United States Patent 6,296,843)
Random mutagenesis and amplification of nucleic acid (United States Patent 6,251,604)
Programmed sequential mutagenesis (United States Patent 6,242,222)
Live mouse mutagenesis systems for testing mutagenic agents in vivo (United States Patent 6,232,524)
Vectors and methods for the mutagenesis of mammalian genes (United States Patent 6,228,639)
Systematic identification of essential genes by in vitro transposon mutagenesis (United States Patent 6,207,384)
Chromosomal mutagenesis in Pichia methanolica (United States Patent 6,183,953)
In vitro scanning saturation mutagenesis of proteins (United States Patent 6,180,341)
Saturation mutagenesis in directed evolution (United States Patent 6,171,820)
Relating to mutagenesis of nucleic acids (United States Patent 6,153,745)
Selective re-extraction of lube extracts to reduce mutagenicity index (United States Patent 6,146,520)
Targeted mutagenesis in living cells using modified oligonucleotides (United States Patent 6,136,601)
Mutagenicity screening method using human DNA polymerase or catalytic polypeptide (United States Patent 6,103,473)
Rapid screening mutagenesis and teratogenesis assay (United States Patent 6,100,089)
Live mouse mutagenesis systems for testing mutagenic agents in vivo (United States Patent 6,054,633)
Site-directed mutagenesis of esterases (United States Patent 6,001,625)
Site-directed mutagenesis modified glycoprotein hormones and methods of use (United States Patent 5,986,068)
Method for knockout mutagenesis in Streptococcus pneumoniae (United States Patent 5,981,281)
Process for identifying mutagens and antimutagens (United States Patent 5,981,191)
Triple-helix forming oligonucleotides for targeted mutagenesis (United States Patent 5,962,426)
Vector for in vitro mutagenesis and use thereof (United States Patent 5,955,363)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,955,056)
Production of enzymes having desired activities by mutagenesis (United States Patent 5,939,250)
Targeted mutagenesis in living cells using modified oligonucleotides (United States Patent 5,935,830)
Circular site-directed mutagenesis (United States Patent 5,932,419)
Method for protection against genotoxic mutagenesis (United States Patent 5,891,856)
Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis (United States Patent 5,891,840)
Eukaryotic high rate mutagenesis system (United States Patent 5,885,827)
Mutagenized DNA molecules encoding modified subunit a of Cholera-toxin (United States Patent 5,874,287)
Method for protection against genotoxic mutagenesis (United States Patent 5,869,338)
Detection system for mutagens that identifies mutagenic changes (United States Patent 5,869,258)
DNA mutagenesis by random fragmentation and reassembly (United States Patent 5,830,721)
Walk-through mutagenesis (United States Patent 5,830,650)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,824,287)
Method of and test kit for mutagenesis testing (United States Patent 5,817,290)
Method of culturing micro-organisms under a mutagenic influence (United States Patent 5,798,253)
Walk-through mutagenesis (United States Patent 5,798,208)
Circular site-directed mutagenesis (United States Patent 5,789,166)
Site-specific mutagenesis and mutant selection utilizing antibiotic-resistant markers encoding gene products having altered substrate specificity (United States Patent 5,780,270)
Modified cholera toxin based on mutagenized subunit A (United States Patent 5,770,203)
Site-directed mutagenesis modified glycoprotein hormones and methods of use (United States Patent 5,705,479)
Mutagenesis methods and compositions (United States Patent 5,702,931)
Methods for detection of mutagens using luminescence gene (United States Patent 5,702,883)
Detection system for mutagens that also identifies mutagenic changes (United States Patent 5,681,737)
Non-mutagenic dye (United States Patent 5,676,708)
Process for inducing cytochrome P-450 enzymes in streptomyces bacteria and determining the mutagenicity of chemicals (United States Patent 5,674,714)
Site-directed mutagenesis modified glycoprotein hormones and methods of use (United States Patent 5,635,475)
Simple and efficient method for site-directed mutageneis with double-stranded plasmid DNA (United States Patent 5,633,157)
Genetic footprinting: insertional mutagenesis and genetic selection (United States Patent 5,612,180)
Process for detecting mutations, transgenic mammal transgenic mammalian cell, and process for testing agents or conditioning for mutagenic properties (United States Patent 5,602,300)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,589,155)
Method for protection against genotoxic mutagenesis (United States Patent 5,567,686)
Method for site-directed mutagenesis (United States Patent 5,556,747)
Method and cell line for testing cytotoxicity and mutagenicity of a chemical (United States Patent 5,525,482)
Transposon consisting of a fragment of the R plasmid pCxM82B, test vectors containing this transposon, and methods of mutagenesis (United States Patent 5,516,669)
Enzymatic inverse polymerase chain reaction library mutagenesis (United States Patent 5,512,463)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,510,099)
Detection of allele - specific mutagens (United States Patent 5,496,699)
Process for reducing polynuclear aromatic mutagenicity by alkylation (United States Patent 5,488,193)
Method for protection against genotoxic mutagenesis (United States Patent 5,488,042)
Human cell line stably expressing 5cDNAS encoding procarcinogen-activating enzymes and related mutagenicity assays (United States Patent 5,429,948)
Site-directed mutagenesis of DNA (United States Patent 5,354,670)
Site-directed mutagenesis modified DNA encoding glycoprotein hormones and methods of use (United States Patent 5,352,779)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,347,075)
Method for in vivo recombination and mutagenesis (United States Patent 5,286,632)
Techniques for producing site-directed mutagenesis of cloned DNA (United States Patent 5,284,760)
Site-directed mutagenesis modified glycoprotein hormones (United States Patent 5,260,421)
Method for identifying mutagenic agents which induce large, multilocus deletions in DNA (United States Patent 5,227,289)
Process for inducing cytochrome P-450 enzymes in Streptomyces bacteria and determining the mutagenicity of chemicals (United States Patent 5,213,971)
Method and cell line for testing mutagenicity of a chemical (United States Patent 5,180,666)
Process for inducing cytochrome P-450 enzymes in streptomyces bacteria and determining the mutagenicity of chemicals (United States Patent 5,169,755)
Method of using T7 DNA polymerase to mutagenize and fill-in DNA (United States Patent 5,145,776)
Circular site-directed mutagenesis (United States Patent 7,132,265)
Chemically modified oligonucleotide for site-directed mutagenesis (United States Patent 7,078,389)
Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating (United States Patent 7,033,781)
System and method for transgenic and targeted mutagenesis screening (United States Patent 6,977,178)
Mutagenesis method (United States Patent 6,949,383)
Method of constructing vectors for homologous recombination directed mutagenesis (United States Patent 6,924,146)
Method for multiple site-directed mutagenesis (United States Patent 6,878,531)
Site-directed mutagenesis of Escherichia coli phytase (United States Patent 6,841,370)
Method for the mutagenesis of nucleotide sequences in plants algae or fungi (United States Patent 6,824,983)
Vectors for gene mutagenesis and gene discovery (United States Patent 6,808,921)
Compositions and methods for random nucleic acid mutagenesis (United States Patent 6,803,216)
Vectors for gene mutagenesis and gene discovery (United States Patent 6,776,988)
Saturation mutageneis in directed evolution (United States Patent 6,764,835)
Method for large scale mutagenesis in tomato plants (United States Patent 6,759,569)
Circular site-directed mutagenesis (United States Patent 6,713,285)
Method for mutagenesis (United States Patent 6,673,610)
Composition and method for detecting mutagens (United States Patent 6,667,153)
Walk-through mutagenesis (United States Patent 6,649,340)
Polynucleotides for mutagenesis in fungus comprising a functional gene in magnaporthe and an impala transposon (United States Patent 6,617,163)
Recombinant nucleic acid sequences and methods for determining both genotoxicity and mutagenicity of a sample and the kinetics of the genotoxicity (United States Patent 6,602,666)
Saturation mutagenesis in directed evolution (United States Patent 6,562,594)
Recombinant nucleic acid sequences and methods for determining both genotoxicity and mutagenicity of a sample and the kinetics of the genotoxicity (United States Patent 6,521,751)
Method for effecting site-directed mutagenesis (United States Patent 6,448,048)
Vectors for gene mutagenesis and gene discovery (United States Patent 6,436,707)
Circular site-directed mutagenesis (United States Patent 6,391,548)
Methods of evolving a polynucleotides by mutagenesis and recombination (United States Patent 6,365,408)
Methods of replicating a DNA molecule for repair of DNA lesion damage or for mutagenesis (United States Patent 6,333,178)
Methods of targeted mutagenesis using triple-helix forming oligonucleotides (United States Patent 6,303,376)
Mutagenized IL 13-based chimeric molecules (United States Patent 6,296,843)
Random mutagenesis and amplification of nucleic acid (United States Patent 6,251,604)
Programmed sequential mutagenesis (United States Patent 6,242,222)
Live mouse mutagenesis systems for testing mutagenic agents in vivo (United States Patent 6,232,524)
Vectors and methods for the mutagenesis of mammalian genes (United States Patent 6,228,639)
Systematic identification of essential genes by in vitro transposon mutagenesis (United States Patent 6,207,384)
Chromosomal mutagenesis in Pichia methanolica (United States Patent 6,183,953)
In vitro scanning saturation mutagenesis of proteins (United States Patent 6,180,341)
Saturation mutagenesis in directed evolution (United States Patent 6,171,820)
Relating to mutagenesis of nucleic acids (United States Patent 6,153,745)
Selective re-extraction of lube extracts to reduce mutagenicity index (United States Patent 6,146,520)
Targeted mutagenesis in living cells using modified oligonucleotides (United States Patent 6,136,601)
Mutagenicity screening method using human DNA polymerase or catalytic polypeptide (United States Patent 6,103,473)
Rapid screening mutagenesis and teratogenesis assay (United States Patent 6,100,089)
Live mouse mutagenesis systems for testing mutagenic agents in vivo (United States Patent 6,054,633)
Site-directed mutagenesis of esterases (United States Patent 6,001,625)
Site-directed mutagenesis modified glycoprotein hormones and methods of use (United States Patent 5,986,068)
Method for knockout mutagenesis in Streptococcus pneumoniae (United States Patent 5,981,281)
Process for identifying mutagens and antimutagens (United States Patent 5,981,191)
Triple-helix forming oligonucleotides for targeted mutagenesis (United States Patent 5,962,426)
Vector for in vitro mutagenesis and use thereof (United States Patent 5,955,363)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,955,056)
Production of enzymes having desired activities by mutagenesis (United States Patent 5,939,250)
Targeted mutagenesis in living cells using modified oligonucleotides (United States Patent 5,935,830)
Circular site-directed mutagenesis (United States Patent 5,932,419)
Method for protection against genotoxic mutagenesis (United States Patent 5,891,856)
Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis (United States Patent 5,891,840)
Eukaryotic high rate mutagenesis system (United States Patent 5,885,827)
Mutagenized DNA molecules encoding modified subunit a of Cholera-toxin (United States Patent 5,874,287)
Method for protection against genotoxic mutagenesis (United States Patent 5,869,338)
Detection system for mutagens that identifies mutagenic changes (United States Patent 5,869,258)
DNA mutagenesis by random fragmentation and reassembly (United States Patent 5,830,721)
Walk-through mutagenesis (United States Patent 5,830,650)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,824,287)
Method of and test kit for mutagenesis testing (United States Patent 5,817,290)
Method of culturing micro-organisms under a mutagenic influence (United States Patent 5,798,253)
Walk-through mutagenesis (United States Patent 5,798,208)
Circular site-directed mutagenesis (United States Patent 5,789,166)
Site-specific mutagenesis and mutant selection utilizing antibiotic-resistant markers encoding gene products having altered substrate specificity (United States Patent 5,780,270)
Modified cholera toxin based on mutagenized subunit A (United States Patent 5,770,203)
Site-directed mutagenesis modified glycoprotein hormones and methods of use (United States Patent 5,705,479)
Mutagenesis methods and compositions (United States Patent 5,702,931)
Methods for detection of mutagens using luminescence gene (United States Patent 5,702,883)
Detection system for mutagens that also identifies mutagenic changes (United States Patent 5,681,737)
Non-mutagenic dye (United States Patent 5,676,708)
Process for inducing cytochrome P-450 enzymes in streptomyces bacteria and determining the mutagenicity of chemicals (United States Patent 5,674,714)
Site-directed mutagenesis modified glycoprotein hormones and methods of use (United States Patent 5,635,475)
Simple and efficient method for site-directed mutageneis with double-stranded plasmid DNA (United States Patent 5,633,157)
Genetic footprinting: insertional mutagenesis and genetic selection (United States Patent 5,612,180)
Process for detecting mutations, transgenic mammal transgenic mammalian cell, and process for testing agents or conditioning for mutagenic properties (United States Patent 5,602,300)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,589,155)
Method for protection against genotoxic mutagenesis (United States Patent 5,567,686)
Method for site-directed mutagenesis (United States Patent 5,556,747)
Method and cell line for testing cytotoxicity and mutagenicity of a chemical (United States Patent 5,525,482)
Transposon consisting of a fragment of the R plasmid pCxM82B, test vectors containing this transposon, and methods of mutagenesis (United States Patent 5,516,669)
Enzymatic inverse polymerase chain reaction library mutagenesis (United States Patent 5,512,463)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,510,099)
Detection of allele - specific mutagens (United States Patent 5,496,699)
Process for reducing polynuclear aromatic mutagenicity by alkylation (United States Patent 5,488,193)
Method for protection against genotoxic mutagenesis (United States Patent 5,488,042)
Human cell line stably expressing 5cDNAS encoding procarcinogen-activating enzymes and related mutagenicity assays (United States Patent 5,429,948)
Site-directed mutagenesis of DNA (United States Patent 5,354,670)
Site-directed mutagenesis modified DNA encoding glycoprotein hormones and methods of use (United States Patent 5,352,779)
Mutagenesis testing using transgenic non-human animals carrying test DNA sequences (United States Patent 5,347,075)
Method for in vivo recombination and mutagenesis (United States Patent 5,286,632)
Techniques for producing site-directed mutagenesis of cloned DNA (United States Patent 5,284,760)
Site-directed mutagenesis modified glycoprotein hormones (United States Patent 5,260,421)
Method for identifying mutagenic agents which induce large, multilocus deletions in DNA (United States Patent 5,227,289)
Process for inducing cytochrome P-450 enzymes in Streptomyces bacteria and determining the mutagenicity of chemicals (United States Patent 5,213,971)
Method and cell line for testing mutagenicity of a chemical (United States Patent 5,180,666)
Process for inducing cytochrome P-450 enzymes in streptomyces bacteria and determining the mutagenicity of chemicals (United States Patent 5,169,755)
Method of using T7 DNA polymerase to mutagenize and fill-in DNA (United States Patent 5,145,776)
Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.