PATENTS RELATED TO BACTERIOPHAGES

Although Dr. Demchick also represents patent seekers with non-microbiological inventions, his doctorate is in microbiology. Microbiology has been the primary focus of his research and teaching. He especially loves dealing with patent searches and applications for involving microbiology.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.

If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.

The following sampling is to give you some sense of the types of bacteriophages related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.

It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Temperature sensitive mutant of bacteriophage T4 endonuclease VII (United States Patent 7,148,339)

Receptor-mediated gene delivery using bacteriophage vectors (United States Patent 7,148,202)

Use of bacterial phage associated lysing enzymes for treating upper respiratory illnesses (United States Patent 7,141,241)

Bacteriophage-mediated immunisation (United States Patent 7,128,916)

Uncoupling of DNA insert propagation and expression of protein for phage display (United States Patent 7,112,435)

Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries (United States Patent 7,078,166)

Chimeric vectors comprising a phage packaging site and a portion derived from the genome of a eukaryotic virus (United States Patent 7,070,930)

Syrup composition containing phage associated lytic enzymes (United States Patent 7,063,837)

Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex (United States Patent 7,049,135)

Phage display of intact domains at high copy number (United States Patent 7,041,441)

Recombinant double-stranded RNA phage, and use of the same (United States Patent 7,018,835)

DNA sequences from staphylococcus aureus bacteriophage 77 that encode anti-microbial polypeptides (United States Patent 6,982,153)

Thermostable phage lambda operator mutants for regulating gene expression (United States Patent 6,964,845)

Method for preventing spoilage of food with bacteriophage (United States Patent 6,955,893)

Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract (United States Patent 6,936,244)

Bacteriophage displaying a.beta. epitopes and method of use (United States Patent 6,919,075)

Lambdoid bacteriophage vectors for expression of foreign proteins (United States Patent 6,884,612)

In vitro process for selecting phage resistant to blood inactivation (United States Patent 6,872,519)

Phage antibodies (United States Patent 6,858,384)

Method to screen phage display libraries with different ligands (United States Patent 6,846,634)

Methods for detecting bacteriophage MS2 (United States Patent 6,841,346)

RNA ligase of bacteriophage RM 378 (United States Patent 6,818,425)

Phage-dependent super-production of biologically active protein and peptides (United States Patent 6,794,162)

Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof (United States Patent 6,787,360)

Development of novel anti-microbial agents based on bacteriophage genomics (United States Patent 6,783,930)

Phage-dependent superproduction of biologically active protein and peptides (United States Patent 6,773,899)

Phage with nuclear localization signal (United States Patent 6,759,231)

Toxin-phage bacteriocide antibiotic and uses thereof (United States Patent 6,759,229)

Methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds (United States Patent 6,753,136)

DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system (United States Patent 6,746,870)

Nucleic acid transfer phage (United States Patent 6,740,524)

High sensitivity phage display biomolecule detection (United States Patent 6,740,492)

Bandage composition containing a phage associated lytic enzyme (United States Patent 6,737,079)

Identification of target structures E.G. in vivo selection method for a phage library (United States Patent 6,727,062)

Filamentous bacteriophage displaying an .beta.-amyloid epitope (United States Patent 6,703,015)

Screening of phage displayed peptides without clearing of the cell culture (United States Patent 6,686,154)

Chewing gum containing phage associated lytic enzymes for treating streptococcal A infections (United States Patent 6,685,937)

Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly) peptide complex (United States Patent 6,667,150)

Bacteriophage-encoded enzymes for the treatment and prevention of dental caries and periodontal diseases (United States Patent 6,635,238)

C1 bacteriophage lytic system (United States Patent 6,608,187)

Production of anti-self antibodies from antibody segment repertoires and displayed on phage (United States Patent 6,593,081)

Modulation of polypeptide display on modified filamentous phage use (United States Patent 6,586,236)

Production of anti-self bodies from antibody segment repertories and displayed on phage (United States Patent 6,582,915)

Bacteriophage assay (United States Patent 6,555,331)

Production of anti-self antibodies from antibody segment repertoires and displayed on phage (United States Patent 6,555,313)

Production of anti-self antibodies from antibody segment repertories and displayed on phage (United States Patent 6,544,731)

Production of anti-self antibodies from antibody segment repertoires and displayed on phage (United States Patent 6,521,404)

Phage display for detergent enzyme activity (United States Patent 6,506,566)

Bacteriophage RM 378 of a thermophilic host organism (United States Patent 6,492,161)

Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof (United States Patent 6,485,912)

Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof (United States Patent 6,482,632)

Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries (United States Patent 6,472,147)

Bacteriophage composition useful in treating food products to prevent bacterial contamination (United States Patent 6,461,608)

Receptor-mediated gene delivery using bacteriophage vectors (United States Patent 6,448,083)

Chimeric vectors comprising a phage packaging site and a portion derived from the genome of a eukaryotic virus (United States Patent 6,440,728)

Bacteria and bacteriophage detection using immobilized enzyme substrates (United States Patent 6,436,661)

Use of bacterial phage associated lysing enzymes for treating dermatological infections (United States Patent 6,432,444)

Use of phage associated lytic enzymes for the rapid detection of bacterial contaminants (United States Patent 6,395,504)

Bacteriophage vectors generated by bacteriophage/plasmid recombination (United States Patent 6,335,185)

Use of bacterial phage associated lysing enzymes for treating bacterial infections of the mouth and teeth (United States Patent 6,335,012)

Recombinant protein having bacteriophage endosialidase enzymatic activity (United States Patent 6,331,425)

Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract (United States Patent 6,326,002)

Modulation of polypeptide display on modified filamentous phage (United States Patent 6,323,004)

Bacteriophage-based transgenic fish for mutation detection (United States Patent 6,307,121)

Phage with nuclear localization signal (United States Patent 6,300,120)

Cheese making with bacteriophage resistant bacteria (United States Patent 6,297,042)

Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections (United States Patent 6,277,399)

Phage-dependent super-production of biologically active protein and peptides (United States Patent 6,268,178)

Phage antibodies (United States Patent 6,265,150)

Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections (United States Patent 6,264,945)

Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract (United States Patent 6,254,866)

Bacterial phage associated lysing enzymes for treating dermatological infections (United States Patent 6,248,324)

Use of bacterial phage associated lysing enzymes for treating various illnesses (United States Patent 6,238,661)

Phage bonded to a nuclear location signal (United States Patent 6,235,521)

Efficient construction of gene targeting using phage-plasmid recombination (United States Patent 6,221,647)

Phage display for detergent enzyme activity (United States Patent 6,194,183)

Modulation of polypeptide display on modified filamentous phage (United States Patent 6,190,908)

Methods of detection utilizing modified bacteriophage (United States Patent 6,190,856)

RNA bacteriophage-based delivery system (United States Patent 6,159,728)

Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof (United States Patent 6,156,574)

Complex inducible promoter system derivable from a phage of a lactic acid bacterium (LAB), and its use in a LAB for production of a desired protein (United States Patent 6,143,525)

Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof (United States Patent 6,130,090)

Efficient construction of gene targeting using phage-plasmid recombination (United States Patent 6,090,629)

Method and device for detecting bacteriophage using contrast-coloring and precipitable dyes (United States Patent 6,090,541)

Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses (United States Patent 6,056,954)

Receptor-mediated gene delivery using bacteriophage vectors (United States Patent 6,054,312)

Bacteriophage library displaying immunoglobulin repertoires with a chemical moiety covalently bound within the binding site: production and selection thereof (United States Patent 6,017,732)

DNA encoding phage resistance protein (United States Patent 5,994,118)

Enzyme for phage resistance (United States Patent 5,972,673)

Method for detecting bacteria using bacteriophage, contrast-coloring dye and precipitable dye (United States Patent 5,958,675)

Nucleic acid sequences and plasmids comprising at least one phage resistance mechanism, bacteria containing them and their use (United States Patent 5,955,332)

DNA encoding phage abortive infection protein from Lactococcus lactis and method of use thereof (United States Patent 5,928,688)

Isolated DNA encoding enzyme for phage resistance (United States Patent 5,925,388)

Method and test kits for detection of bacteriophage (United States Patent 5,914,240)

DNA encoding phage abortive infection protein from Lactococcus lactis and method of use thereof (United States Patent 5,910,571)

Production of anti-self antibodies from antibody segment repertoires and displayed on phage (United States Patent 5,885,793)

Cloning and expression of the gene for bacteriophage T7 RNA polymerase (United States Patent 5,869,320)

Device and method for phage-based antibiotic susceptibility testing (United States Patent 5,858,693)

Isolation and production of catalytic antibodies using phage technology (United States Patent 5,855,885)

Overexpression of recombinant bacteriophage T4 endonuclease VII and uses thereof (United States Patent 5,824,530)

Temperature sensitive mutant of bacteriophage T4 endonuclease VII (United States Patent 7,148,339)

Receptor-mediated gene delivery using bacteriophage vectors (United States Patent 7,148,202)

Use of bacterial phage associated lysing enzymes for treating upper respiratory illnesses (United States Patent 7,141,241)

Bacteriophage-mediated immunisation (United States Patent 7,128,916)

Uncoupling of DNA insert propagation and expression of protein for phage display (United States Patent 7,112,435)

Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries (United States Patent 7,078,166)

Chimeric vectors comprising a phage packaging site and a portion derived from the genome of a eukaryotic virus (United States Patent 7,070,930)

Syrup composition containing phage associated lytic enzymes (United States Patent 7,063,837)

Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex (United States Patent 7,049,135)

Phage display of intact domains at high copy number (United States Patent 7,041,441)

Recombinant double-stranded RNA phage, and use of the same (United States Patent 7,018,835)

DNA sequences from staphylococcus aureus bacteriophage 77 that encode anti-microbial polypeptides (United States Patent 6,982,153)

Thermostable phage lambda operator mutants for regulating gene expression (United States Patent 6,964,845)

Method for preventing spoilage of food with bacteriophage (United States Patent 6,955,893)

Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract (United States Patent 6,936,244)

Bacteriophage displaying a.beta. epitopes and method of use (United States Patent 6,919,075)

Lambdoid bacteriophage vectors for expression of foreign proteins (United States Patent 6,884,612)

In vitro process for selecting phage resistant to blood inactivation (United States Patent 6,872,519)

Phage antibodies (United States Patent 6,858,384)

Method to screen phage display libraries with different ligands (United States Patent 6,846,634)

Methods for detecting bacteriophage MS2 (United States Patent 6,841,346)

RNA ligase of bacteriophage RM 378 (United States Patent 6,818,425)

Phage-dependent super-production of biologically active protein and peptides (United States Patent 6,794,162)

Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof (United States Patent 6,787,360)

Development of novel anti-microbial agents based on bacteriophage genomics (United States Patent 6,783,930)

Phage-dependent superproduction of biologically active protein and peptides (United States Patent 6,773,899)

Phage with nuclear localization signal (United States Patent 6,759,231)

Toxin-phage bacteriocide antibiotic and uses thereof (United States Patent 6,759,229)

Methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds (United States Patent 6,753,136)

DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system (United States Patent 6,746,870)

Nucleic acid transfer phage (United States Patent 6,740,524)

High sensitivity phage display biomolecule detection (United States Patent 6,740,492)

Bandage composition containing a phage associated lytic enzyme (United States Patent 6,737,079)

Identification of target structures E.G. in vivo selection method for a phage library (United States Patent 6,727,062)

Filamentous bacteriophage displaying an .beta.-amyloid epitope (United States Patent 6,703,015)

Screening of phage displayed peptides without clearing of the cell culture (United States Patent 6,686,154)

Chewing gum containing phage associated lytic enzymes for treating streptococcal A infections (United States Patent 6,685,937)

Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly) peptide complex (United States Patent 6,667,150)

Bacteriophage-encoded enzymes for the treatment and prevention of dental caries and periodontal diseases (United States Patent 6,635,238)

C1 bacteriophage lytic system (United States Patent 6,608,187)

Production of anti-self antibodies from antibody segment repertoires and displayed on phage (United States Patent 6,593,081)

Modulation of polypeptide display on modified filamentous phage use (United States Patent 6,586,236)

Production of anti-self bodies from antibody segment repertories and displayed on phage (United States Patent 6,582,915)

Bacteriophage assay (United States Patent 6,555,331)

Production of anti-self antibodies from antibody segment repertoires and displayed on phage (United States Patent 6,555,313)

Production of anti-self antibodies from antibody segment repertories and displayed on phage (United States Patent 6,544,731)

Production of anti-self antibodies from antibody segment repertoires and displayed on phage (United States Patent 6,521,404)

Phage display for detergent enzyme activity (United States Patent 6,506,566)

Bacteriophage RM 378 of a thermophilic host organism (United States Patent 6,492,161)

Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof (United States Patent 6,485,912)

Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof (United States Patent 6,482,632)

Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries (United States Patent 6,472,147)

Bacteriophage composition useful in treating food products to prevent bacterial contamination (United States Patent 6,461,608)

Receptor-mediated gene delivery using bacteriophage vectors (United States Patent 6,448,083)

Chimeric vectors comprising a phage packaging site and a portion derived from the genome of a eukaryotic virus (United States Patent 6,440,728)

Bacteria and bacteriophage detection using immobilized enzyme substrates (United States Patent 6,436,661)

Use of bacterial phage associated lysing enzymes for treating dermatological infections (United States Patent 6,432,444)

Use of phage associated lytic enzymes for the rapid detection of bacterial contaminants (United States Patent 6,395,504)

Bacteriophage vectors generated by bacteriophage/plasmid recombination (United States Patent 6,335,185)

Use of bacterial phage associated lysing enzymes for treating bacterial infections of the mouth and teeth (United States Patent 6,335,012)

Recombinant protein having bacteriophage endosialidase enzymatic activity (United States Patent 6,331,425)

Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract (United States Patent 6,326,002)

Modulation of polypeptide display on modified filamentous phage (United States Patent 6,323,004)

Bacteriophage-based transgenic fish for mutation detection (United States Patent 6,307,121)

Phage with nuclear localization signal (United States Patent 6,300,120)

Cheese making with bacteriophage resistant bacteria (United States Patent 6,297,042)

Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections (United States Patent 6,277,399)

Phage-dependent super-production of biologically active protein and peptides (United States Patent 6,268,178)

Phage antibodies (United States Patent 6,265,150)

Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections (United States Patent 6,264,945)

Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract (United States Patent 6,254,866)

Bacterial phage associated lysing enzymes for treating dermatological infections (United States Patent 6,248,324)

Use of bacterial phage associated lysing enzymes for treating various illnesses (United States Patent 6,238,661)

Phage bonded to a nuclear location signal (United States Patent 6,235,521)

Efficient construction of gene targeting using phage-plasmid recombination (United States Patent 6,221,647)

Phage display for detergent enzyme activity (United States Patent 6,194,183)

Modulation of polypeptide display on modified filamentous phage (United States Patent 6,190,908)

Methods of detection utilizing modified bacteriophage (United States Patent 6,190,856)

RNA bacteriophage-based delivery system (United States Patent 6,159,728)

Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof (United States Patent 6,156,574)

Complex inducible promoter system derivable from a phage of a lactic acid bacterium (LAB), and its use in a LAB for production of a desired protein (United States Patent 6,143,525)

Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof (United States Patent 6,130,090)

Efficient construction of gene targeting using phage-plasmid recombination (United States Patent 6,090,629)

Method and device for detecting bacteriophage using contrast-coloring and precipitable dyes (United States Patent 6,090,541)

Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses (United States Patent 6,056,954)

Receptor-mediated gene delivery using bacteriophage vectors (United States Patent 6,054,312)

Bacteriophage library displaying immunoglobulin repertoires with a chemical moiety covalently bound within the binding site: production and selection thereof (United States Patent 6,017,732)

DNA encoding phage resistance protein (United States Patent 5,994,118)

Enzyme for phage resistance (United States Patent 5,972,673)

Method for detecting bacteria using bacteriophage, contrast-coloring dye and precipitable dye (United States Patent 5,958,675)

Nucleic acid sequences and plasmids comprising at least one phage resistance mechanism, bacteria containing them and their use (United States Patent 5,955,332)

DNA encoding phage abortive infection protein from Lactococcus lactis and method of use thereof (United States Patent 5,928,688)

Isolated DNA encoding enzyme for phage resistance (United States Patent 5,925,388)

Method and test kits for detection of bacteriophage (United States Patent 5,914,240)

DNA encoding phage abortive infection protein from Lactococcus lactis and method of use thereof (United States Patent 5,910,571)

Production of anti-self antibodies from antibody segment repertoires and displayed on phage (United States Patent 5,885,793)

Cloning and expression of the gene for bacteriophage T7 RNA polymerase (United States Patent 5,869,320)

Device and method for phage-based antibiotic susceptibility testing (United States Patent 5,858,693)

Isolation and production of catalytic antibodies using phage technology (United States Patent 5,855,885)

Overexpression of recombinant bacteriophage T4 endonuclease VII and uses thereof (United States Patent 5,824,530)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.