PATENTS RELATED TO PHAGOCYTES

Although Dr. Demchick also represents patent seekers with non-biological inventions, his doctorate is in biology. Biology has been the primary focus of his research and teaching. He especially loves dealing with patent searches and applications for involving biology.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.

If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.

The following sampling is to give you some sense of the types of phagocytes related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.

It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Cysteine variants of granulocyte-macrophage colony-stimulating factor (United States Patent 7,148,333)

Inhibitors of macrophage migration inhibitory factor and methods for identifying the same (United States Patent 7,129,236)

Methods of identifying g-couple receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof (United States Patent 7,129,055)

Inhibitors of macrophage migration inhibitory factor and methods for identifying the same (United States Patent 7,105,519)

Methods for modulating macrophage proliferation using polyamine analogs (United States Patent 7,087,648)

Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof (United States Patent 7,018,627)

Method of inhibiting overactivity of phagocytes or lymphocytes in an individual (United States Patent 7,008,666)

Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque (United States Patent 6,974,567)

Means and methods for fibroblast-like or macrophage-like cell transduction (United States Patent 6,869,936)

Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque (United States Patent 6,869,590)

Macrophage-infecting parasites expressing a granulocyte macrophage colony stimulated factor (United States Patent 6,855,537)

T20/DP178 is an activator of human phagocyte formyl peptide receptors (United States Patent 6,830,893)

Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions (United States Patent 6,821,516)

Polynucleotides encoding macrophage derived chemokine (United States Patent 6,790,947)

DNA encoding human apoB48R: a monocyte-macrophage apolipoprotein B48 receptor gene and protein (United States Patent 6,740,735)

Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same (United States Patent 6,737,513)

Cell compositions containing macrophages, presenting anti-infectious and hematopoietic properties (United States Patent 6,737,051)

Reversal of proinflammatory response by ligating the macrophage Fc.gamma.RI receptor (United States Patent 6,660,266)

Macrophage inflammatory protein-4 (MIP-4) polynucleotides (United States Patent 6,623,942)

Macrophage derived chemokine (MDC) as an anti-viral agent for the treatment and prevention of lentivirus infection (United States Patent 6,548,631)

Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions (United States Patent 6,540,994)

Diagnosis and treatment of cancer having clonal macrophage involvement (United States Patent 6,537,523)

Cell surface molecule-induced macrophage activation (United States Patent 6,506,891)

Humanized antibodies to Fc receptors for immunoglobulin G on human mononuclear phagocytes (United States Patent 6,500,931)

Macrophage inflammatory protein-4 (MIP-4) polypeptides (United States Patent 6,488,925)

Macrophage scavenger receptor antagonists (United States Patent 6,458,845)

Anti-parasitic helminth macrophage migration inhibitory factor antibodies and uses thereof (United States Patent 6,455,039)

Screening assay for the identification of inhibitors for macrophage migration inhibitory factor (United States Patent 6,420,188)

Method for reducing adverse effects of a human 70kDa mediator which results from endotoxin stimulation of macrophages (United States Patent 6,419,927)

Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis (United States Patent 6,410,269)

Method of treating humans with diseases characterized by high secretion of cytokines from macrophage cells (United States Patent 6,407,068)

Retinal pigment epithelial protein which suppresses neutrophil macrophage superoxide generation (United States Patent 6,395,874)

Process for fractionating polyethylene glycol (PEG) --protein adducts and an adduct of PEG and granulocyt-macrophage colony stimulating factor (United States Patent 6,384,195)

Use of mononuclear phagocytes in in vivo imaging of hypoxic/ischaemic tissue (United States Patent 6,379,647)

Macrophage-infecting parasites expressing a granulocyte macrophage colony stimulating factor (United States Patent 6,331,304)

Macrophage derived chemokine (United States Patent 6,320,023)

Antisense modulation of macrophage migration inhibitory factor expression (United States Patent 6,268,151)

Mononuclear phagocytes and their use to promote axonal regeneration (United States Patent 6,267,955)

Fluorescence resonance energy transfer screening assay for the identification of compounds that are capable of abrogating macrophage-tropic HIV-1 cell fusion (United States Patent 6,261,763)

Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof (United States Patent 6,258,527)

Macrophage scavenger receptor antagonists for use in the treatment of cardiovascular diseases (United States Patent 6,255,298)

Analogs of macrophage stimulating protein (United States Patent 6,248,560)

Dendritic-marker expressing macrophage cultures and methods of reactivating latent virus (United States Patent 6,225,048)

Determination of a genetic risk factor for infection and other diseases, and detection of activated phagocytes (United States Patent 6,221,591)

Process for preparing macrophages, kits, and compositions for the use of this process (United States Patent 6,221,576)

Recombinant cells from the monocyte-macrophage cell line for gene therapy (United States Patent 6,210,963)

Parasitic helminth macrophage migration inhibitory factor proteins, nucleic acid molecules, and uses thereof (United States Patent 6,207,158)

Human macrophage metalloproteinase (United States Patent 6,204,043)

Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes (United States Patent 6,197,749)

Cell surface molecule-induced macrophage activation (United States Patent 6,197,294)

DNA encoding human monocyte-macrophage apolipoprotein B receptor gene and protein (United States Patent 6,194,558)

Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes (United States Patent 6,156,302)

Human macrophage metalloelastase (United States Patent 6,150,152)

Method and system for cultivating macrophages (United States Patent 6,146,890)

Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria (United States Patent 6,143,551)

Process for preparing macrophages, kits, and compositions for the use of this process (United States Patent 6,140,122)

Compositions of mononuclear phagocytes useful for promoting axonal regeneration (United States Patent 6,117,424)

Composition comprising an antibody to macrophage-derived inflammatory mediator (MIP-2) (United States Patent 6,103,234)

Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant (United States Patent 6,096,313)

Isothermal transcription based amplification assay for the detection and quantitation of macrophage derived chemokine RNA (United States Patent 6,093,542)

Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation (United States Patent 6,071,493)

Macrophage receptor with a collagenous domain (United States Patent 6,063,901)

Method for making activated neutrophils recognizable to macrophages (United States Patent 6,054,315)

Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions (United States Patent 6,051,432)

Macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 6,046,309)

Macrophage migration inhibitory factor as diagnostic and prognostic marker for metastatic adenocarcinoma (United States Patent 6,043,044)

Human macrophage antigen (United States Patent 6,034,219)

Macrophage stimulating protein for the treatment of pathologies of the nervous system (United States Patent 6,030,949)

Composition comprising antibody to macrophage-derived inflammatory mediator (MIP-.alpha. 1 and MIP-1.beta.) (United States Patent 6,019,969)

Composition and methods for the inhibition of phagocytes (United States Patent 6,017,883)

Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions (United States Patent 6,001,351)

Method for measuring the binding sites for macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 5,989,836)

Macrophage Migration Inhibitory Factor-3 (United States Patent 5,986,060)

Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes (United States Patent 5,985,270)

Analogs of macrophage stimulating protein (United States Patent 5,948,892)

Methods of treating granulocyte-macrophage progenitor cell-derived blood cell dysfunction (United States Patent 5,942,222)

Recombinant primate granulocyte macrophage-colony stimulating factor (United States Patent 5,942,221)

G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof (United States Patent 5,939,320)

Modified forms of granulocyte macrophage-colony stimulating factor as antagonists (United States Patent 5,939,063)

Macrophage inflammatory protein variants (United States Patent 5,936,067)

Macrophage derived chemokine and chemokine analogs (United States Patent 5,932,703)

Canine granulocyte macrophage colony stimulating factor (United States Patent 5,925,343)

Macrophage stimulating protein variant and method for producing the same (United States Patent 5,916,770)

Recombinant human granulocyte-macrophage-colony stimulating factor (GM-CSF) (United States Patent 5,891,429)

Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct of PEG and granulocyte-macrophage colony stimulating factor (United States Patent 5,880,255)

Macrophage lipid chemoattractant (United States Patent 5,869,537)

Natural resistance associated macrophage protein and uses thereof (United States Patent 5,869,247)

Macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 5,863,535)

Compositions and methods for the inhibition of phagocytes (United States Patent 5,861,475)

Kaposi's sarcoma-associated herpesvirus (KSHV) viral macrophage inflammatory protein-1.alpha. II (vMIP-1.alpha. II) and uses thereof (United States Patent 5,854,418)

Macrophage-derived inflammatory mediator (MIP-1 .alpha. and MIP-1 .beta.) (United States Patent 5,849,873)

Macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 5,817,763)

Expression of macrophage inducible proteins (MIPS) in yeast cells (United States Patent 5,814,484)

Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, & in vitro generation of dendritic cells and macrophages (United States Patent 5,811,297)

Process for preparing macrophages, kits, and composition for the use of this process (United States Patent 5,804,442)

Methods of use of mononuclear phagocytes to promote axonal regeneration (United States Patent 5,800,812)

Human macrophage antigen (United States Patent 5,792,648)

DNA encoding macrophage inflammatory protein-1.gamma. (United States Patent 5,770,402)

Treatment of disease and conditions associated with macrophage infiltration (United States Patent 5,767,106)

Antibody to macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 5,760,186)

Cysteine variants of granulocyte-macrophage colony-stimulating factor (United States Patent 7,148,333)

Inhibitors of macrophage migration inhibitory factor and methods for identifying the same (United States Patent 7,129,236)

Methods of identifying g-couple receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof (United States Patent 7,129,055)

Inhibitors of macrophage migration inhibitory factor and methods for identifying the same (United States Patent 7,105,519)

Methods for modulating macrophage proliferation using polyamine analogs (United States Patent 7,087,648)

Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof (United States Patent 7,018,627)

Method of inhibiting overactivity of phagocytes or lymphocytes in an individual (United States Patent 7,008,666)

Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque (United States Patent 6,974,567)

Means and methods for fibroblast-like or macrophage-like cell transduction (United States Patent 6,869,936)

Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque (United States Patent 6,869,590)

Macrophage-infecting parasites expressing a granulocyte macrophage colony stimulated factor (United States Patent 6,855,537)

T20/DP178 is an activator of human phagocyte formyl peptide receptors (United States Patent 6,830,893)

Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions (United States Patent 6,821,516)

Polynucleotides encoding macrophage derived chemokine (United States Patent 6,790,947)

DNA encoding human apoB48R: a monocyte-macrophage apolipoprotein B48 receptor gene and protein (United States Patent 6,740,735)

Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same (United States Patent 6,737,513)

Cell compositions containing macrophages, presenting anti-infectious and hematopoietic properties (United States Patent 6,737,051)

Reversal of proinflammatory response by ligating the macrophage Fc.gamma.RI receptor (United States Patent 6,660,266)

Macrophage inflammatory protein-4 (MIP-4) polynucleotides (United States Patent 6,623,942)

Macrophage derived chemokine (MDC) as an anti-viral agent for the treatment and prevention of lentivirus infection (United States Patent 6,548,631)

Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions (United States Patent 6,540,994)

Diagnosis and treatment of cancer having clonal macrophage involvement (United States Patent 6,537,523)

Cell surface molecule-induced macrophage activation (United States Patent 6,506,891)

Humanized antibodies to Fc receptors for immunoglobulin G on human mononuclear phagocytes (United States Patent 6,500,931)

Macrophage inflammatory protein-4 (MIP-4) polypeptides (United States Patent 6,488,925)

Macrophage scavenger receptor antagonists (United States Patent 6,458,845)

Anti-parasitic helminth macrophage migration inhibitory factor antibodies and uses thereof (United States Patent 6,455,039)

Screening assay for the identification of inhibitors for macrophage migration inhibitory factor (United States Patent 6,420,188)

Method for reducing adverse effects of a human 70kDa mediator which results from endotoxin stimulation of macrophages (United States Patent 6,419,927)

Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis (United States Patent 6,410,269)

Method of treating humans with diseases characterized by high secretion of cytokines from macrophage cells (United States Patent 6,407,068)

Retinal pigment epithelial protein which suppresses neutrophil macrophage superoxide generation (United States Patent 6,395,874)

Process for fractionating polyethylene glycol (PEG) --protein adducts and an adduct of PEG and granulocyt-macrophage colony stimulating factor (United States Patent 6,384,195)

Use of mononuclear phagocytes in in vivo imaging of hypoxic/ischaemic tissue (United States Patent 6,379,647)

Macrophage-infecting parasites expressing a granulocyte macrophage colony stimulating factor (United States Patent 6,331,304)

Macrophage derived chemokine (United States Patent 6,320,023)

Antisense modulation of macrophage migration inhibitory factor expression (United States Patent 6,268,151)

Mononuclear phagocytes and their use to promote axonal regeneration (United States Patent 6,267,955)

Fluorescence resonance energy transfer screening assay for the identification of compounds that are capable of abrogating macrophage-tropic HIV-1 cell fusion (United States Patent 6,261,763)

Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof (United States Patent 6,258,527)

Macrophage scavenger receptor antagonists for use in the treatment of cardiovascular diseases (United States Patent 6,255,298)

Analogs of macrophage stimulating protein (United States Patent 6,248,560)

Dendritic-marker expressing macrophage cultures and methods of reactivating latent virus (United States Patent 6,225,048)

Determination of a genetic risk factor for infection and other diseases, and detection of activated phagocytes (United States Patent 6,221,591)

Process for preparing macrophages, kits, and compositions for the use of this process (United States Patent 6,221,576)

Recombinant cells from the monocyte-macrophage cell line for gene therapy (United States Patent 6,210,963)

Parasitic helminth macrophage migration inhibitory factor proteins, nucleic acid molecules, and uses thereof (United States Patent 6,207,158)

Human macrophage metalloproteinase (United States Patent 6,204,043)

Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes (United States Patent 6,197,749)

Cell surface molecule-induced macrophage activation (United States Patent 6,197,294)

DNA encoding human monocyte-macrophage apolipoprotein B receptor gene and protein (United States Patent 6,194,558)

Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes (United States Patent 6,156,302)

Human macrophage metalloelastase (United States Patent 6,150,152)

Method and system for cultivating macrophages (United States Patent 6,146,890)

Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria (United States Patent 6,143,551)

Process for preparing macrophages, kits, and compositions for the use of this process (United States Patent 6,140,122)

Compositions of mononuclear phagocytes useful for promoting axonal regeneration (United States Patent 6,117,424)

Composition comprising an antibody to macrophage-derived inflammatory mediator (MIP-2) (United States Patent 6,103,234)

Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant (United States Patent 6,096,313)

Isothermal transcription based amplification assay for the detection and quantitation of macrophage derived chemokine RNA (United States Patent 6,093,542)

Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation (United States Patent 6,071,493)

Macrophage receptor with a collagenous domain (United States Patent 6,063,901)

Method for making activated neutrophils recognizable to macrophages (United States Patent 6,054,315)

Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions (United States Patent 6,051,432)

Macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 6,046,309)

Macrophage migration inhibitory factor as diagnostic and prognostic marker for metastatic adenocarcinoma (United States Patent 6,043,044)

Human macrophage antigen (United States Patent 6,034,219)

Macrophage stimulating protein for the treatment of pathologies of the nervous system (United States Patent 6,030,949)

Composition comprising antibody to macrophage-derived inflammatory mediator (MIP-.alpha. 1 and MIP-1.beta.) (United States Patent 6,019,969)

Composition and methods for the inhibition of phagocytes (United States Patent 6,017,883)

Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions (United States Patent 6,001,351)

Method for measuring the binding sites for macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 5,989,836)

Macrophage Migration Inhibitory Factor-3 (United States Patent 5,986,060)

Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes (United States Patent 5,985,270)

Analogs of macrophage stimulating protein (United States Patent 5,948,892)

Methods of treating granulocyte-macrophage progenitor cell-derived blood cell dysfunction (United States Patent 5,942,222)

Recombinant primate granulocyte macrophage-colony stimulating factor (United States Patent 5,942,221)

G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof (United States Patent 5,939,320)

Modified forms of granulocyte macrophage-colony stimulating factor as antagonists (United States Patent 5,939,063)

Macrophage inflammatory protein variants (United States Patent 5,936,067)

Macrophage derived chemokine and chemokine analogs (United States Patent 5,932,703)

Canine granulocyte macrophage colony stimulating factor (United States Patent 5,925,343)

Macrophage stimulating protein variant and method for producing the same (United States Patent 5,916,770)

Recombinant human granulocyte-macrophage-colony stimulating factor (GM-CSF) (United States Patent 5,891,429)

Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct of PEG and granulocyte-macrophage colony stimulating factor (United States Patent 5,880,255)

Macrophage lipid chemoattractant (United States Patent 5,869,537)

Natural resistance associated macrophage protein and uses thereof (United States Patent 5,869,247)

Macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 5,863,535)

Compositions and methods for the inhibition of phagocytes (United States Patent 5,861,475)

Kaposi's sarcoma-associated herpesvirus (KSHV) viral macrophage inflammatory protein-1.alpha. II (vMIP-1.alpha. II) and uses thereof (United States Patent 5,854,418)

Macrophage-derived inflammatory mediator (MIP-1 .alpha. and MIP-1 .beta.) (United States Patent 5,849,873)

Macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 5,817,763)

Expression of macrophage inducible proteins (MIPS) in yeast cells (United States Patent 5,814,484)

Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, & in vitro generation of dendritic cells and macrophages (United States Patent 5,811,297)

Process for preparing macrophages, kits, and composition for the use of this process (United States Patent 5,804,442)

Methods of use of mononuclear phagocytes to promote axonal regeneration (United States Patent 5,800,812)

Human macrophage antigen (United States Patent 5,792,648)

DNA encoding macrophage inflammatory protein-1.gamma. (United States Patent 5,770,402)

Treatment of disease and conditions associated with macrophage infiltration (United States Patent 5,767,106)

Antibody to macrophage-derived inflammatory mediator (MIP-1.alpha. and MIP-1.beta.) (United States Patent 5,760,186)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.