PATENTS RELATED TO STREPTOMYCES

Although Dr. Demchick also represents patent seekers with non-microbiological inventions, his doctorate is in microbiology. Microbiology has been the primary focus of his research and teaching. He especially loves dealing with patent searches and applications for involving microbiology.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.

If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.

The following sampling is to give you some sense of the types of streptomyces related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.

It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Methods related to Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins (United States Patent 7,029,887)

Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for .beta.-lactam antibiotic biosynthesis (United States Patent 6,964,865)

E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production (United States Patent 6,939,691)

Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and streptomyces hosts capable of improved clavulanic acid production (United States Patent 6,936,458)

Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments (United States Patent 6,902,548)

Metabolite from streptomyces strain NRRL accession No. B-30145 and mutants thereof for controlling plant diseases (United States Patent 6,852,317)

Strain of Streptomyces griseus (United States Patent 6,844,173)

AveC gene product from Streptomyces hygroscopicus (United States Patent 6,833,263)

Epoxide hydrolases from streptomyces (United States Patent 6,828,115)

Isolation of biosynthesis genes for pseudo-oligosaccharides from Streptomyces glaucescens GLA.O, and their use (United States Patent 6,825,013)

Process for the production of polyhydroxyoctanoate by streptomyces lividans (United States Patent 6,692,945)

Modified Streptomyces host cells for increased avermectin production and methods of making the same (United States Patent 6,689,611)

Streptomyces strain with insecticidal activity and method of using as an insecticide (United States Patent 6,682,925)

Recombinant Streptomyces hygroscopicus host cells that produce 17-desmethylrapamycin (United States Patent 6,670,168)

STREPTOMYCES MEGASPORUS SD5, PROCESS FOR THE ISOLATION THEREOF, NOVEL FIBRINOLYTIC ENZYME PREPARED THEREFROM, PROCESS FOR THE PRODUCTION OF SAID ENZYME AND METHOD OF TREATMENT OF THROMBOLYTIC DISORDERS USING SAID ENZYME (United States Patent 6,638,503)

Directing the ratio of B2:B1 avermectins in Streptomyces avermitilis host cells (United States Patent 6,632,673)

Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient (United States Patent 6,608,045)

Streptomyces strain with potential anti-microbial activity against phytopathogenic fungi (United States Patent 6,558,940)

Strain of Streptomyces for controlling plant diseases (United States Patent 6,524,577)

Strain of streptomyces for the preparation of an alkaline protease inhibitor (United States Patent 6,514,748)

Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins (United States Patent 6,511,841)

Strain of streptomyces, and relevant uses thereof (United States Patent 6,509,373)

Alkaline tolerant dextranase from streptomyces anulatus (United States Patent 6,509,184)

Methods related to Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins (United States Patent 6,509,159)

Polyketide synthase genes from Streptomyces venezuelae (United States Patent 6,503,741)

Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains, process for production and uses thereof (United States Patent 6,399,583)

Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from Streptomyces avermitilis (United States Patent 6,399,324)

Microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain (United States Patent 6,306,629)

Isolation of the biosynthesis genes for pseudo-oligosaccharides from streptomyces glaucescens GLA.O, and their use (United States Patent 6,306,627)

Nucleic acids encoding narbonolide polyketide synthase enzymes from streptomyces narbonensis (United States Patent 6,303,767)

Strains of streptomyces and relevant uses thereof (United States Patent 6,287,845)

Strains of Streptomyces and relevant uses thereof (United States Patent 6,274,157)

Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins (United States Patent 6,248,579)

Pacidamycins produced by Streptomyces coeruleorubidus (United States Patent 6,228,842)

Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804 (United States Patent 6,207,428)

Streptomyces avermitilis regulatory genes for increased avermectin production (United States Patent 6,197,591)

Strains of streptomyces producing endothelin antagonistic peptides (United States Patent 6,194,195)

Strain of streptomyces, and relevant uses thereof (United States Patent 6,193,964)

Streptomyces strains and process to produce single streptogramin component (United States Patent 6,180,392)

Alkaline protease from streptomyces sp. and method for preparing the same (United States Patent 6,156,557)

Nucleic acid probes and methods for detecting Streptomyces enterococci (United States Patent 5,994,059)

Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804 (United States Patent 5,985,625)

Use of streptomyces bacteria to control plant pathogens and degrade turf thatch (United States Patent 5,968,503)

Natamycin-containing streptomyces biomass and its use in animal feed (United States Patent 5,902,579)

Process for producing .epsilon.-poly-L-lysine with immobilized Streptomyces albulus (United States Patent 5,900,363)

Streptomyces proteases and methods for improved secretion of recombinantly-expressed proteins (United States Patent 5,856,166)

Streptomyces microorganism useful for the preparation of (R)-baclofen from the racemic mixture (United States Patent 5,843,765)

Process for production of tricyclo compounds with streptomyces (United States Patent 5,830,717)

Melanin production by streptomyces (United States Patent 5,814,495)

Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804 (United States Patent 5,780,274)

Production aflastatin A from streptomyces sp., a pharmaceutical composition and methods of use (United States Patent 5,773,263)

Process for enantioselective hydrolysis of .alpha.-(2-amino)-phenyl-benzenemethanol ester type compounds using bacillus, pseudomonas or streptomyces (United States Patent 5,770,438)

Peptides having farnesyl transferase inhibiting properties and strain of genus streptomyces for producing same (United States Patent 5,734,013)

Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from Streptomyces avermitilis (United States Patent 5,728,561)

Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis (United States Patent 5,707,839)

Process for inducing cytochrome P-450 enzymes in streptomyces bacteria and determining the mutagenicity of chemicals (United States Patent 5,674,714)

Protease from Streptomyces fradiae (United States Patent 5,665,586)

Alkaline serine protease streptomyces griseus var. alkaliphus having enhanced stability against urea or guanidine (United States Patent 5,646,028)

Strain of Streptomyces for the production of tricyclo compounds (United States Patent 5,624,842)

Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces (United States Patent 5,622,866)

Process for producing parasiticidal milbemycin derivatives by culturing streptomyces (United States Patent 5,620,874)

Streptomyces proteases and improved streptomyces strains for expression of peptides and polypeptides (United States Patent 5,616,485)

Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors (United States Patent 5,612,217)

Biologically pure culture of Streptomyces hygroscopicus ATCC 53718 capable of producing antibiotic compounds (United States Patent 5,573,946)

Nematocidal and fungicidal Streptomyces dicklowii biopesticide (United States Patent 5,549,889)

Streptomyces viridodiastaticus subsp. "Littus" NRRL-21082N capable of producing antibiotics (United States Patent 5,536,660)

Legionella specific antibiotic produced by Streptomyces sp AL91 access ion number KCCM 10055 (United States Patent 5,529,924)

Use of streptomyces bacteria to control plant pathogens (United States Patent 5,527,526)

Fungicidal antibiotic producing Streptomyces sp. NCIMB 40212 (United States Patent 5,516,686)

Isolation and characterization of a novel protease from Streptomyces lividans (United States Patent 5,516,685)

Expression system comprising DNA encoding the signal peptide of protease B from Streptomyces griseus (United States Patent 5,514,590)

A process for producing legionella specific antibiotic using Streptomyces sp. AL91 (United States Patent 5,503,997)

Method of removing color from wood pulp using xylanase from streptomyces roseiscleroticus NRRL B-11019 (United States Patent 5,498,534)

Protein protease inhibitors from streptomyces (United States Patent 5,498,529)

Streptomyces braegensis strain and its cultivation in a process for producing C.sub.9 -desoxo-FK-520 (United States Patent 5,494,820)

Constitutive expression of P450soy and ferredoxin-soy in Streptomyces (United States Patent 5,466,590)

Gal operon of streptomyces (United States Patent 5,435,730)

Biologically pure culture of the microorganism, streptomyces cyaneogriseus subspecies noncyanogenus, or a mutant thereof (United States Patent 5,418,168)

Use of Streptomyces WYEC 108 to control plant pathogens (United States Patent 5,403,584)

Antibiotic AB-041 derived from Streptomyces sp. NCIMB 40428, herbicidal compositions, and methods of use (United States Patent 5,401,709)

Methods for transforming streptomyces and other actinomycetes (United States Patent 5,393,665)

Streptomyces NCIMB 40227 active in the biostimulation of agricultural production (United States Patent 5,391,493)

Restriction endonuclease SgfI from Streptomyces griseoruber (United States Patent 5,391,487)

Transposable elements from streptomyces and other organisms (United States Patent 5,382,527)

Xylanase from streptomyces roseiscleroticus NRRL-11019 for removing color from kraft wood pulps (United States Patent 5,369,024)

Compounds produced by a strain of Streptomyces exfoliatus (United States Patent 5,332,574)

Promoter screening vector, streptomyces promoters found therewith, and the isolation and use thereof (United States Patent 5,328,998)

10'desmethoxystreptonigrin production by Streptomyces albus (United States Patent 5,320,955)

Strain of streptomyces avermitilis capable of glycosylating avermectin compounds at the 13- and 14A positions (United States Patent 5,312,753)

Streptomyces NCIMB 40277 active in the biostimulation of agricultural production (United States Patent 5,302,578)

Strain of streptomyces for producing avermectins and processes therewith (United States Patent 5,292,647)

Protein protease inhibitors from streptomyces (United States Patent 5,279,939)

Fungicidal antibiotic from Streptomyces NCIMB 40212 (United States Patent 5,279,829)

Arylsulfatase from streptomyces (United States Patent 5,270,196)

Streptomyces spectabilis strains employed for producing streptovaricin C (United States Patent 5,266,484)

Methlating enzyme from streptomyces MA6858 (United States Patent 5,264,355)

Method for isolating transposable elements from streptomyces (United States Patent 5,264,354)

Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use (United States Patent 5,252,474)

Process for the production of furans and lactones from streptomyces (United States Patent 5,252,472)

Methods related to Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins (United States Patent 7,029,887)

Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for .beta.-lactam antibiotic biosynthesis (United States Patent 6,964,865)

E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production (United States Patent 6,939,691)

Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and streptomyces hosts capable of improved clavulanic acid production (United States Patent 6,936,458)

Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments (United States Patent 6,902,548)

Metabolite from streptomyces strain NRRL accession No. B-30145 and mutants thereof for controlling plant diseases (United States Patent 6,852,317)

Strain of Streptomyces griseus (United States Patent 6,844,173)

AveC gene product from Streptomyces hygroscopicus (United States Patent 6,833,263)

Epoxide hydrolases from streptomyces (United States Patent 6,828,115)

Isolation of biosynthesis genes for pseudo-oligosaccharides from Streptomyces glaucescens GLA.O, and their use (United States Patent 6,825,013)

Process for the production of polyhydroxyoctanoate by streptomyces lividans (United States Patent 6,692,945)

Modified Streptomyces host cells for increased avermectin production and methods of making the same (United States Patent 6,689,611)

Streptomyces strain with insecticidal activity and method of using as an insecticide (United States Patent 6,682,925)

Recombinant Streptomyces hygroscopicus host cells that produce 17-desmethylrapamycin (United States Patent 6,670,168)

STREPTOMYCES MEGASPORUS SD5, PROCESS FOR THE ISOLATION THEREOF, NOVEL FIBRINOLYTIC ENZYME PREPARED THEREFROM, PROCESS FOR THE PRODUCTION OF SAID ENZYME AND METHOD OF TREATMENT OF THROMBOLYTIC DISORDERS USING SAID ENZYME (United States Patent 6,638,503)

Directing the ratio of B2:B1 avermectins in Streptomyces avermitilis host cells (United States Patent 6,632,673)

Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient (United States Patent 6,608,045)

Streptomyces strain with potential anti-microbial activity against phytopathogenic fungi (United States Patent 6,558,940)

Strain of Streptomyces for controlling plant diseases (United States Patent 6,524,577)

Strain of streptomyces for the preparation of an alkaline protease inhibitor (United States Patent 6,514,748)

Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins (United States Patent 6,511,841)

Strain of streptomyces, and relevant uses thereof (United States Patent 6,509,373)

Alkaline tolerant dextranase from streptomyces anulatus (United States Patent 6,509,184)

Methods related to Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins (United States Patent 6,509,159)

Polyketide synthase genes from Streptomyces venezuelae (United States Patent 6,503,741)

Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains, process for production and uses thereof (United States Patent 6,399,583)

Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from Streptomyces avermitilis (United States Patent 6,399,324)

Microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain (United States Patent 6,306,629)

Isolation of the biosynthesis genes for pseudo-oligosaccharides from streptomyces glaucescens GLA.O, and their use (United States Patent 6,306,627)

Nucleic acids encoding narbonolide polyketide synthase enzymes from streptomyces narbonensis (United States Patent 6,303,767)

Strains of streptomyces and relevant uses thereof (United States Patent 6,287,845)

Strains of Streptomyces and relevant uses thereof (United States Patent 6,274,157)

Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins (United States Patent 6,248,579)

Pacidamycins produced by Streptomyces coeruleorubidus (United States Patent 6,228,842)

Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804 (United States Patent 6,207,428)

Streptomyces avermitilis regulatory genes for increased avermectin production (United States Patent 6,197,591)

Strains of streptomyces producing endothelin antagonistic peptides (United States Patent 6,194,195)

Strain of streptomyces, and relevant uses thereof (United States Patent 6,193,964)

Streptomyces strains and process to produce single streptogramin component (United States Patent 6,180,392)

Alkaline protease from streptomyces sp. and method for preparing the same (United States Patent 6,156,557)

Nucleic acid probes and methods for detecting Streptomyces enterococci (United States Patent 5,994,059)

Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804 (United States Patent 5,985,625)

Use of streptomyces bacteria to control plant pathogens and degrade turf thatch (United States Patent 5,968,503)

Natamycin-containing streptomyces biomass and its use in animal feed (United States Patent 5,902,579)

Process for producing .epsilon.-poly-L-lysine with immobilized Streptomyces albulus (United States Patent 5,900,363)

Streptomyces proteases and methods for improved secretion of recombinantly-expressed proteins (United States Patent 5,856,166)

Streptomyces microorganism useful for the preparation of (R)-baclofen from the racemic mixture (United States Patent 5,843,765)

Process for production of tricyclo compounds with streptomyces (United States Patent 5,830,717)

Melanin production by streptomyces (United States Patent 5,814,495)

Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804 (United States Patent 5,780,274)

Production aflastatin A from streptomyces sp., a pharmaceutical composition and methods of use (United States Patent 5,773,263)

Process for enantioselective hydrolysis of .alpha.-(2-amino)-phenyl-benzenemethanol ester type compounds using bacillus, pseudomonas or streptomyces (United States Patent 5,770,438)

Peptides having farnesyl transferase inhibiting properties and strain of genus streptomyces for producing same (United States Patent 5,734,013)

Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from Streptomyces avermitilis (United States Patent 5,728,561)

Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis (United States Patent 5,707,839)

Process for inducing cytochrome P-450 enzymes in streptomyces bacteria and determining the mutagenicity of chemicals (United States Patent 5,674,714)

Protease from Streptomyces fradiae (United States Patent 5,665,586)

Alkaline serine protease streptomyces griseus var. alkaliphus having enhanced stability against urea or guanidine (United States Patent 5,646,028)

Strain of Streptomyces for the production of tricyclo compounds (United States Patent 5,624,842)

Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces (United States Patent 5,622,866)

Process for producing parasiticidal milbemycin derivatives by culturing streptomyces (United States Patent 5,620,874)

Streptomyces proteases and improved streptomyces strains for expression of peptides and polypeptides (United States Patent 5,616,485)

Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors (United States Patent 5,612,217)

Biologically pure culture of Streptomyces hygroscopicus ATCC 53718 capable of producing antibiotic compounds (United States Patent 5,573,946)

Nematocidal and fungicidal Streptomyces dicklowii biopesticide (United States Patent 5,549,889)

Streptomyces viridodiastaticus subsp. "Littus" NRRL-21082N capable of producing antibiotics (United States Patent 5,536,660)

Legionella specific antibiotic produced by Streptomyces sp AL91 access ion number KCCM 10055 (United States Patent 5,529,924)

Use of streptomyces bacteria to control plant pathogens (United States Patent 5,527,526)

Fungicidal antibiotic producing Streptomyces sp. NCIMB 40212 (United States Patent 5,516,686)

Isolation and characterization of a novel protease from Streptomyces lividans (United States Patent 5,516,685)

Expression system comprising DNA encoding the signal peptide of protease B from Streptomyces griseus (United States Patent 5,514,590)

A process for producing legionella specific antibiotic using Streptomyces sp. AL91 (United States Patent 5,503,997)

Method of removing color from wood pulp using xylanase from streptomyces roseiscleroticus NRRL B-11019 (United States Patent 5,498,534)

Protein protease inhibitors from streptomyces (United States Patent 5,498,529)

Streptomyces braegensis strain and its cultivation in a process for producing C.sub.9 -desoxo-FK-520 (United States Patent 5,494,820)

Constitutive expression of P450soy and ferredoxin-soy in Streptomyces (United States Patent 5,466,590)

Gal operon of streptomyces (United States Patent 5,435,730)

Biologically pure culture of the microorganism, streptomyces cyaneogriseus subspecies noncyanogenus, or a mutant thereof (United States Patent 5,418,168)

Use of Streptomyces WYEC 108 to control plant pathogens (United States Patent 5,403,584)

Antibiotic AB-041 derived from Streptomyces sp. NCIMB 40428, herbicidal compositions, and methods of use (United States Patent 5,401,709)

Methods for transforming streptomyces and other actinomycetes (United States Patent 5,393,665)

Streptomyces NCIMB 40227 active in the biostimulation of agricultural production (United States Patent 5,391,493)

Restriction endonuclease SgfI from Streptomyces griseoruber (United States Patent 5,391,487)

Transposable elements from streptomyces and other organisms (United States Patent 5,382,527)

Xylanase from streptomyces roseiscleroticus NRRL-11019 for removing color from kraft wood pulps (United States Patent 5,369,024)

Compounds produced by a strain of Streptomyces exfoliatus (United States Patent 5,332,574)

Promoter screening vector, streptomyces promoters found therewith, and the isolation and use thereof (United States Patent 5,328,998)

10'desmethoxystreptonigrin production by Streptomyces albus (United States Patent 5,320,955)

Strain of streptomyces avermitilis capable of glycosylating avermectin compounds at the 13- and 14A positions (United States Patent 5,312,753)

Streptomyces NCIMB 40277 active in the biostimulation of agricultural production (United States Patent 5,302,578)

Strain of streptomyces for producing avermectins and processes therewith (United States Patent 5,292,647)

Protein protease inhibitors from streptomyces (United States Patent 5,279,939)

Fungicidal antibiotic from Streptomyces NCIMB 40212 (United States Patent 5,279,829)

Arylsulfatase from streptomyces (United States Patent 5,270,196)

Streptomyces spectabilis strains employed for producing streptovaricin C (United States Patent 5,266,484)

Methlating enzyme from streptomyces MA6858 (United States Patent 5,264,355)

Method for isolating transposable elements from streptomyces (United States Patent 5,264,354)

Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use (United States Patent 5,252,474)

Process for the production of furans and lactones from streptomyces (United States Patent 5,252,472)

Methods related to Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins (United States Patent 7,029,887)

Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for .beta.-lactam antibiotic biosynthesis (United States Patent 6,964,865)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.