PATENTS RELATED TO TUBERCULOSIS

Although Dr. Demchick also represents patent seekers with non-microbiological inventions, his doctorate is in microbiology. Microbiology has been the primary focus of his research and teaching. He especially loves dealing with patent searches and applications for involving microbiology.

Dr. Demchick is a scientist with a quarter of a century of research experience in academic, industrial and governmental settings.

If you are considering patent protection for an invention, Dr. Demchick will be glad to discuss the matter with you. There is no charge for an initial discussion.

The following sampling is to give you some sense of the types of tuberculosis related inventions which have received United States patent protection. The patent list is not exhaustive and is certainly not a substitute for a proper patent search . It should be noted that only U.S. Patents are included.

It should be noted that spelling, form and typographical errors in the original patents are preserved here.

Methods and apparatus to prevent colds, influenzaes, tuberculosis and opportunistic infections of the human respiratory system (United States Patent 7,150,888)

Compounds and methods for diagnosis of tuberculosis (United States Patent 7,122,196)

Detection of CD8+ T cell responses to M. tuberculosis (United States Patent 7,115,361)

Latent human tuberculosis model, diagnostic antigens, and methods of use (United States Patent 7,105,170)

Mycobacterial proteins, microorganisms producing them and their use for vaccines and the detection of tuberculosis (United States Patent 7,101,555)

Detection of rpoB sequences of Mycobacterium tuberculosis (United States Patent 7,094,542)

Mycobacterium tuberculosis superoxide dismutase (United States Patent 7,094,403)

Compounds and methods for diagnosis and immunotherapy of tuberculosis (United States Patent 7,087,713)

32-kDa protein derived from Mycobacterium tuberculosis and related peptides (United States Patent 7,083,797)

Fusion proteins of mycobacterium tuberculosis (United States Patent 7,083,796)

Desaturase antigen of mycobacterium tuberculosis (United States Patent 7,071,320)

Fusion proteins of mycobacterium tuberculosis antigens and their uses (United States Patent 7,064,195)

Hybrids of M. tuberculosis antigens (United States Patent 7,037,510)

Fusion proteins of Mycobacterium tuberculosis (United States Patent 7,026,465)

Mycobacterium tuberculosis immunization (United States Patent 7,022,320)

Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins (United States Patent 7,009,042)

Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis (United States Patent 7,009,041)

M. tuberculosis antigens (United States Patent 6,991,797)

TB diagnostic based on antigens from M. tuberculosis (United States Patent 6,982,085)

Fusion proteins of Mycobacterium tuberculosis antigens and their uses (United States Patent 6,977,069)

Compounds and methods for immunotherapy and diagnosis of tuberculosis (United States Patent 6,962,710)

Method for testing drug susceptibility of Mycobacterium tuberculosis (United States Patent 6,951,733)

rpoB gene fragments and a method for the diagnosis and identification of Mycobacterium tuberculosis and non-tuberculosis Mycobacterial strains (United States Patent 6,951,718)

Compounds and methods for diagnosis of tuberculosis (United States Patent 6,949,246)

Methods of diagnosing multidrug resistant tuberculosis (United States Patent 6,905,822)

Rapid lateral flow assay for determining exposure to Mycobacterium tuberculosis and other mycobacteria (United States Patent 6,841,159)

Naphthoquinone derivatives and their use in the treatment and control of tuberculosis (United States Patent 6,835,755)

METHOD FOR IDENTIFYING MYCOBACTERIUM TUBERCULOSIS AND MYCOBACTERIA OTHER THAN TUBERCULOSIS, TOGETHER WITH DETECTING RESISTANCE TO AN ANTITUBERCULOSIS DRUG OF MYCOBACTERIA OBTAINED BY MUTATION OF RPOB GENE (United States Patent 6,815,165)

Process for the preparation of a vaccine for the treatment of tuberculosis and other intracellular infections diseases and the vaccine produced by the process (United States Patent 6,783,765)

Tuberculosis vaccine (United States Patent 6,776,993)

Molecular differences between species of the M. tuberculosis complex (United States Patent 6,686,166)

Methyl esters of substituted 4-oxo-2-butenoic acid for treatment of tuberculosis (United States Patent 6,683,110)

Mycobacterial proteins, microorganisms producing them and their use for vaccines and for the detection of tuberculosis (United States Patent 6,676,945)

Tuberculosis vaccine (United States Patent 6,673,353)

2-oxo-1, 4-benzoxazine compounds for treatment of tuberculosis (United States Patent 6,649,610)

Reporter gene based method for the screening of anti-tuberculosis drugs by using essential and regulatory genes of mycobacteria as drug target (United States Patent 6,645,505)

Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis (United States Patent 6,641,814)

Mycobacterium polypeptides and nucleic acids encoding them for diagnosis and control of tuberculosis (United States Patent 6,638,511)

Fusion proteins of Mycobacterium tuberculosis antigens and their uses (United States Patent 6,627,198)

Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use (United States Patent 6,613,881)

Rapid immunoassay to detect infection with Mycobacterium tuberculosis (United States Patent 6,599,691)

Mycobacterium tuberculosis specific proteins and genes, mixtures of antigens and uses thereof (United States Patent 6,596,281)

Compounds and methods for immunotherapy and diagnosis of tuberculosis (United States Patent 6,592,877)

Nucleic acid and amino acid sequences relating to mycobacterium tuberculosis and leprae for diagnostics and therapeutics (United States Patent 6,583,266)

Desaturase antigen of mycobacterium tuberculosis (United States Patent 6,582,925)

Agar medium for the growth of Mycobacterium tuberculosis (United States Patent 6,579,694)

Mycobacterium tuberculosis DNA sequences encoding immunostimulatory peptides and methods for using same (United States Patent 6,572,865)

Recombinant M. tuberculosis auxotrophic for leucine and vaccines using same (United States Patent 6,562,348)

Compounds for diagnosis of tuberculosis and methods for their use (United States Patent 6,555,653)

Desaturase antigen of Mycobacterium tuberculosis (United States Patent 6,551,808)

Monoclonal antibodies to mycobacterium tuberculosis and a modified ELISA assay (United States Patent 6,545,130)

Fusion proteins of mycobacterium tuberculosis antigens and their uses (United States Patent 6,544,522)

Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypetides and peptides in the diagnostic of tuberculosis (United States Patent 6,531,138)

Mycobacterium tuberculosis superoxide dismutase (United States Patent 6,517,845)

DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof (United States Patent 6,509,151)

Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis (United States Patent 6,465,633)

Compounds and methods for diagnosis of tuberculosis (United States Patent 6,458,366)

Polynucleotide functionally coding for the LHP protein from Mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same (United States Patent 6,436,409)

DNA molecule encoding for cellular uptake of mycobacterium tuberculosis and uses thereof (United States Patent 6,399,764)

Polynucleotide tuberculosis vaccine (United States Patent 6,384,018)

Mycrobacterial proteins, microorganisms producing same and uses of said proteins in vaccines and for detecting tuberculosis (United States Patent 6,379,902)

Nucleic acid encoding M. tuberculosis algu protein (United States Patent 6,355,469)

M. tuberculosis RNA polymerase alpha subunit (United States Patent 6,355,464)

Compositions and methods for the prevention and treatment of M. tuberculosis infection (United States Patent 6,350,456)

Compounds and methods for diagnosis of tuberculosis (United States Patent 6,338,852)

Mycobacterial proteins, microorganisms producing them and their use for vaccines and for the detection of tuberculosis (United States Patent 6,335,181)

DNA sequences for strain analysis in Mycobacterium tuberculosis (United States Patent 6,294,328)

Molecular differences between species of the M. tuberculosis complex (United States Patent 6,291,190)

Compounds and methods for immunotherapy and diagnosis of tuberculosis (United States Patent 6,290,969)

Carbohydrate complex extracted from Mycobacterium tuberculosis and process for the preparation thereof (United States Patent 6,274,356)

Mycobacterium tuberculosis specific DNA fragment (United States Patent 6,242,585)

Mycobacterium tuberculosis DNA sequences encoding immunostimulatory peptides (United States Patent 6,228,371)

DNA molecule fragments encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof (United States Patent 6,224,881)

Antibodies Which Bind Mycobacterial Tuberculosis Proteins (United States Patent 6,221,353)

DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof (United States Patent 6,214,543)

Desaturase antigen of Mycobacterium tuberculosis (United States Patent 6,204,038)

Detection of M. tuberculosis complex via reverse transcriptase SDA (United States Patent 6,204,026)

DNA molecule conferring on Mycobacterium tuberculosis resistance against antimicrobial reactive oxygen and nitrogen intermediates (United States Patent 6,177,086)

Detection of M. tuberculosis complex via reverse transcriptase SDA (United States Patent 6,156,508)

Rapid detection of antibiotic resistance in mycobacterium tuberculosis (United States Patent 6,124,098)

Diagnostic skin test for tuberculosis (United States Patent 6,120,776)

Mycobacterium tuberculosis specific DNA fragment (United States Patent 6,114,514)

Method of identification of animals resistant or susceptible to disease such as ruminant brucellosis, tuberculosis, paratuberculosis and salmonellosis (United States Patent 6,114,118)

Hybrid plasmid for 38 kDa antigen of M. tuberculosis (United States Patent 6,110,469)

Mycobacterium tuberculosis specific proteins and genes, mixtures of anitgens and uses thereof (United States Patent 6,087,163)

Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis (United States Patent 6,083,922)

Detection and differentiation of mycobacterium tuberculosis complex bacteria by direct variant repeat oligotyping (United States Patent 6,074,820)

DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof (United States Patent 6,072,048)

Desaturase antigen of mycobacterium tuberculosis (United States Patent 6,010,855)

DNA molecule encoding for cellular uptake of mycobacterium tuberculosis and uses thereof (United States Patent 6,008,201)

Method of identifying compounds that regulate the binding of M. tuberculosis sigF to M. tuberculosis orfX (United States Patent 6,004,764)

Method for treating Mycobacterium tuberculosis (United States Patent 5,998,420)

12-kDa protein derived from M. Tuberculosis useful for treatment of autoimmune diseases (United States Patent 5,976,543)

Tuberculosis vaccine (United States Patent 5,955,077)

Mutations in the katG gene useful for detection of M. tuberculosis (United States Patent 5,922,575)

Super fast tuberculosis diagnosis and sensitivity testing method (United States Patent 5,922,282)

Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis (United States Patent 5,916,558)

Detecting Mycobacterium tuberculosis by nucleic acid sequence amplification (United States Patent 5,908,744)

Nucleic acid probes to mycobacterium tuberculosis (United States Patent 5,906,917)

SecA gene of mycobacterium tuberculosis and related methods and compositions (United States Patent 5,885,828)

Methods and apparatus to prevent colds, influenzaes, tuberculosis and opportunistic infections of the human respiratory system (United States Patent 7,150,888)

Compounds and methods for diagnosis of tuberculosis (United States Patent 7,122,196)

Detection of CD8+ T cell responses to M. tuberculosis (United States Patent 7,115,361)

Latent human tuberculosis model, diagnostic antigens, and methods of use (United States Patent 7,105,170)

Mycobacterial proteins, microorganisms producing them and their use for vaccines and the detection of tuberculosis (United States Patent 7,101,555)

Detection of rpoB sequences of Mycobacterium tuberculosis (United States Patent 7,094,542)

Mycobacterium tuberculosis superoxide dismutase (United States Patent 7,094,403)

Compounds and methods for diagnosis and immunotherapy of tuberculosis (United States Patent 7,087,713)

32-kDa protein derived from Mycobacterium tuberculosis and related peptides (United States Patent 7,083,797)

Fusion proteins of mycobacterium tuberculosis (United States Patent 7,083,796)

Desaturase antigen of mycobacterium tuberculosis (United States Patent 7,071,320)

Fusion proteins of mycobacterium tuberculosis antigens and their uses (United States Patent 7,064,195)

Hybrids of M. tuberculosis antigens (United States Patent 7,037,510)

Fusion proteins of Mycobacterium tuberculosis (United States Patent 7,026,465)

Mycobacterium tuberculosis immunization (United States Patent 7,022,320)

Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins (United States Patent 7,009,042)

Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis (United States Patent 7,009,041)

M. tuberculosis antigens (United States Patent 6,991,797)

TB diagnostic based on antigens from M. tuberculosis (United States Patent 6,982,085)

Fusion proteins of Mycobacterium tuberculosis antigens and their uses (United States Patent 6,977,069)

Compounds and methods for immunotherapy and diagnosis of tuberculosis (United States Patent 6,962,710)

Method for testing drug susceptibility of Mycobacterium tuberculosis (United States Patent 6,951,733)

rpoB gene fragments and a method for the diagnosis and identification of Mycobacterium tuberculosis and non-tuberculosis Mycobacterial strains (United States Patent 6,951,718)

Compounds and methods for diagnosis of tuberculosis (United States Patent 6,949,246)

Methods of diagnosing multidrug resistant tuberculosis (United States Patent 6,905,822)

Rapid lateral flow assay for determining exposure to Mycobacterium tuberculosis and other mycobacteria (United States Patent 6,841,159)

Naphthoquinone derivatives and their use in the treatment and control of tuberculosis (United States Patent 6,835,755)

METHOD FOR IDENTIFYING MYCOBACTERIUM TUBERCULOSIS AND MYCOBACTERIA OTHER THAN TUBERCULOSIS, TOGETHER WITH DETECTING RESISTANCE TO AN ANTITUBERCULOSIS DRUG OF MYCOBACTERIA OBTAINED BY MUTATION OF RPOB GENE (United States Patent 6,815,165)

Process for the preparation of a vaccine for the treatment of tuberculosis and other intracellular infections diseases and the vaccine produced by the process (United States Patent 6,783,765)

Tuberculosis vaccine (United States Patent 6,776,993)

Molecular differences between species of the M. tuberculosis complex (United States Patent 6,686,166)

Methyl esters of substituted 4-oxo-2-butenoic acid for treatment of tuberculosis (United States Patent 6,683,110)

Mycobacterial proteins, microorganisms producing them and their use for vaccines and for the detection of tuberculosis (United States Patent 6,676,945)

Tuberculosis vaccine (United States Patent 6,673,353)

2-oxo-1, 4-benzoxazine compounds for treatment of tuberculosis (United States Patent 6,649,610)

Reporter gene based method for the screening of anti-tuberculosis drugs by using essential and regulatory genes of mycobacteria as drug target (United States Patent 6,645,505)

Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis (United States Patent 6,641,814)

Mycobacterium polypeptides and nucleic acids encoding them for diagnosis and control of tuberculosis (United States Patent 6,638,511)

Fusion proteins of Mycobacterium tuberculosis antigens and their uses (United States Patent 6,627,198)

Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use (United States Patent 6,613,881)

Rapid immunoassay to detect infection with Mycobacterium tuberculosis (United States Patent 6,599,691)

Mycobacterium tuberculosis specific proteins and genes, mixtures of antigens and uses thereof (United States Patent 6,596,281)

Compounds and methods for immunotherapy and diagnosis of tuberculosis (United States Patent 6,592,877)

Nucleic acid and amino acid sequences relating to mycobacterium tuberculosis and leprae for diagnostics and therapeutics (United States Patent 6,583,266)

Desaturase antigen of mycobacterium tuberculosis (United States Patent 6,582,925)

Agar medium for the growth of Mycobacterium tuberculosis (United States Patent 6,579,694)

Mycobacterium tuberculosis DNA sequences encoding immunostimulatory peptides and methods for using same (United States Patent 6,572,865)

Recombinant M. tuberculosis auxotrophic for leucine and vaccines using same (United States Patent 6,562,348)

Compounds for diagnosis of tuberculosis and methods for their use (United States Patent 6,555,653)

Desaturase antigen of Mycobacterium tuberculosis (United States Patent 6,551,808)

Monoclonal antibodies to mycobacterium tuberculosis and a modified ELISA assay (United States Patent 6,545,130)

Fusion proteins of mycobacterium tuberculosis antigens and their uses (United States Patent 6,544,522)

Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypetides and peptides in the diagnostic of tuberculosis (United States Patent 6,531,138)

Mycobacterium tuberculosis superoxide dismutase (United States Patent 6,517,845)

DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof (United States Patent 6,509,151)

Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis (United States Patent 6,465,633)

Compounds and methods for diagnosis of tuberculosis (United States Patent 6,458,366)

Polynucleotide functionally coding for the LHP protein from Mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same (United States Patent 6,436,409)

DNA molecule encoding for cellular uptake of mycobacterium tuberculosis and uses thereof (United States Patent 6,399,764)

Polynucleotide tuberculosis vaccine (United States Patent 6,384,018)

Mycrobacterial proteins, microorganisms producing same and uses of said proteins in vaccines and for detecting tuberculosis (United States Patent 6,379,902)

Nucleic acid encoding M. tuberculosis algu protein (United States Patent 6,355,469)

M. tuberculosis RNA polymerase alpha subunit (United States Patent 6,355,464)

Compositions and methods for the prevention and treatment of M. tuberculosis infection (United States Patent 6,350,456)

Compounds and methods for diagnosis of tuberculosis (United States Patent 6,338,852)

Mycobacterial proteins, microorganisms producing them and their use for vaccines and for the detection of tuberculosis (United States Patent 6,335,181)

DNA sequences for strain analysis in Mycobacterium tuberculosis (United States Patent 6,294,328)

Molecular differences between species of the M. tuberculosis complex (United States Patent 6,291,190)

Compounds and methods for immunotherapy and diagnosis of tuberculosis (United States Patent 6,290,969)

Carbohydrate complex extracted from Mycobacterium tuberculosis and process for the preparation thereof (United States Patent 6,274,356)

Mycobacterium tuberculosis specific DNA fragment (United States Patent 6,242,585)

Mycobacterium tuberculosis DNA sequences encoding immunostimulatory peptides (United States Patent 6,228,371)

DNA molecule fragments encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof (United States Patent 6,224,881)

Antibodies Which Bind Mycobacterial Tuberculosis Proteins (United States Patent 6,221,353)

DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof (United States Patent 6,214,543)

Desaturase antigen of Mycobacterium tuberculosis (United States Patent 6,204,038)

Detection of M. tuberculosis complex via reverse transcriptase SDA (United States Patent 6,204,026)

DNA molecule conferring on Mycobacterium tuberculosis resistance against antimicrobial reactive oxygen and nitrogen intermediates (United States Patent 6,177,086)

Detection of M. tuberculosis complex via reverse transcriptase SDA (United States Patent 6,156,508)

Rapid detection of antibiotic resistance in mycobacterium tuberculosis (United States Patent 6,124,098)

Diagnostic skin test for tuberculosis (United States Patent 6,120,776)

Mycobacterium tuberculosis specific DNA fragment (United States Patent 6,114,514)

Method of identification of animals resistant or susceptible to disease such as ruminant brucellosis, tuberculosis, paratuberculosis and salmonellosis (United States Patent 6,114,118)

Hybrid plasmid for 38 kDa antigen of M. tuberculosis (United States Patent 6,110,469)

Mycobacterium tuberculosis specific proteins and genes, mixtures of anitgens and uses thereof (United States Patent 6,087,163)

Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis (United States Patent 6,083,922)

Detection and differentiation of mycobacterium tuberculosis complex bacteria by direct variant repeat oligotyping (United States Patent 6,074,820)

DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof (United States Patent 6,072,048)

Desaturase antigen of mycobacterium tuberculosis (United States Patent 6,010,855)

DNA molecule encoding for cellular uptake of mycobacterium tuberculosis and uses thereof (United States Patent 6,008,201)

Method of identifying compounds that regulate the binding of M. tuberculosis sigF to M. tuberculosis orfX (United States Patent 6,004,764)

Method for treating Mycobacterium tuberculosis (United States Patent 5,998,420)

12-kDa protein derived from M. Tuberculosis useful for treatment of autoimmune diseases (United States Patent 5,976,543)

Tuberculosis vaccine (United States Patent 5,955,077)

Mutations in the katG gene useful for detection of M. tuberculosis (United States Patent 5,922,575)

Super fast tuberculosis diagnosis and sensitivity testing method (United States Patent 5,922,282)

Recombinant polypeptides and peptides, nucleic acids coding for the same and use of these polypeptides and peptides in the diagnostic of tuberculosis (United States Patent 5,916,558)

Detecting Mycobacterium tuberculosis by nucleic acid sequence amplification (United States Patent 5,908,744)

Nucleic acid probes to mycobacterium tuberculosis (United States Patent 5,906,917)

SecA gene of mycobacterium tuberculosis and related methods and compositions (United States Patent 5,885,828)

Although his recognition as a registered patent agent permits him to represent others in all patent matters before the United States Patent and Trademark Office, Dr. Demchick limits his practice to patent matters involving inventions for which he is confident that his expertise will allow him to serve his client well. He will gladly discuss whether he is comfortable handling cases involving inventions in a particular field. He will err on the side of declining cases if he has uncertainty about his ability to do what is needed in the case. Dr. Demchick does not represent clients in court. However, he refers clients to a patent attorney who does represent others in court, if it appears likely that patent related representation in court is appropriate. Dr. Demchick prepares and files non-provisional (regular) patent applications and provisional patent applications. He prepares and files utility patent applications and design patent applications. He prepares and files U.S. patent applications and international patent applications under the Patent Cooperation Treaty (PCT). He prepares and files applications to enter the U.S. National Phase for inventions for which international patent applications (PCT) were already filed. One of the matters he discusses with each client or potential client is which type of application(s) best meets that client's needs. He usually does a patent search (patentability search) as part of the preparation of a patent application. He discusses the value of patent searching with each inventor before agreeing to prepare a patent application for that inventor.